TABLE 2.
Characteristics of colorectal cancer patients diagnosed 1995–2016, by medical history of solid organ transplantation. The odds ratios (OR) and relative risk ratios (RRR) compare organ transplant recipients (OTRs) to non-transplanted cancer patients (No Tx) with respect to cancer characteristics and treatment.
| Characteristics | All colorectal cancer | Colon cancer | Rectal cancer | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OTRs | No Tx | OR a , b (95% CI) | p-value | OTRs | No Tx | OR a , b (95% CI) | p-value | OTRs | No Tx | OR a , b (95% CI) | p-value | |
| N (%) | N (%) | N (%) | N (%) | N (%) | N (%) | |||||||
| Cancer stage | 0.08 | 0.11 | 0.47 | |||||||||
| I-II | 33 (40) | 187 (43) | Base outcome | 25 (37) | 138 (40) | Base outcome | 8 (50) | 49 (53) | Base outcome | |||
| III | 19 (23) | 134 (31) | 0.81 (0.43–1.53) | 15 (22) | 102 (30) | 0.82 (0.39–1.71) | 4 (25) | 32 (34) | 0.90 (0.23–3.55) | |||
| IV | 31 (37) | 113 (26) | 1.53 (0.89–2.64) | 27 (40) | 101 (30) | 1.68 (0.89–3.19) | 4 (25) | 12 (14) | 2.35 (0.52–10.6) | |||
| Missing | 15 | 40 | 6 | 11 | 9 | 29 | ||||||
| Preoperative MDT meeting | 0.64 | 0.77 | 0.59 | |||||||||
| Yes | 53 (60) | 276 (64) | 0.88 (0.52–1.49) | 40 (55) | 204 (58) | 0.91 (0.50–1.67) | 13 (81) | 72 (88) | 0.65 (0.13–3.13) | |||
| No | 36 (40) | 157 (36) | Base outcome | 33 (45) | 147 (42) | Base outcome | 3 (19) | 10 (12) | Base outcome | |||
| Missing | 9 | 41 | 0 | 1 | 9 | 40 | ||||||
| Abdominal surgery c | 0.03 | 0.04 | 0.32 | |||||||||
| Yes | 47 (90) | 306 (96) | 0.27 (0.08–0.90) | 37 (93) | 232 (97) | 0.16 (0.03–0.94) | 10 (83) | 74 (93) | 0.33 (0.04–2.98) | |||
| No | 5 (10) | 14 (4) | Base outcome | 3 (8) | 8 (3) | Base outcome | 2 (17) | 6 (8) | Base outcome | |||
| Missing | 0 | 1 | 0 | 0 | 0 | 1 | ||||||
Abbreviations: OTR, organ transplant recipient; Tx, transplantation; OR, odds ratio; CI, confidence interval; N, number; MDT, multidisciplinary team.
All reported ORs and relative risk ratios (RRR) refer to the contrast between OTRs, and non-transplanted cancer patients (No Tx), where the latter constitute the reference group. The regression models were adjusted for the matching factors cancer location (colon or rectum), sex, age at diagnosis (±1 year), and year of CRC, diagnosis, as well as region, cardiovascular comorbidity, attained level of education, and chronic dialysis at cancer diagnosis.
RRR from multinomial regression for reporting association with cancer stage.
Among stage I-III patients.