TABLE 4.

Hazard ratios of cancer-specific death, overall death, and relapse, among stage I-III colorectal cancer patients treated with abdominal surgery, stratified by medical history of solid organ transplantation, with 5 years of follow-up. Administrative censoring occurred on Dec 31st, 2017, for cancer-specific and overall death, and on June 4th, 2022, for relapse.

Selection	Start of follow-up	Outcome	All colorectal cancer			Colon cancer			Rectal cancer
			OTRs	No Tx	HR a (95% CI)	OTRs	No Tx	HR a (95% CI)	OTRs	No Tx	HR a (95% CI)
			N (%)	N (%)		N (%)	N (%)		N (%)	N (%)
All patients			98 (100)	474 (100)		73 (100)	352 (100)		25 (100)	122 (100)
	Date of diagnosis	Cancer-specific death	37 (38)	127 (27)	2.16 (1.48–3.15)	30 (41)	102 (29)	2.50 (1.64–3.81)	7 (28)	25 (20)	1.43 (0.58–3.52)
		Overall death	61 (62)	179 (38)	2.11 (1.55–2.88)	50 (68)	137 (39)	2.59 (1.83–3.66)	11 (44)	42 (34)	1.21 (0.59–2.48)
Stage I-III cancer and abdominal surgery b			47 (100)	306 (100)		37 (100)	232 (100)		10 (100)	74 (100)
	Date of surgery	Cancer-specific death	10 (21)	39 (13)	3.50 (1.64–7.43)	6 (16)	29 (13)	2.85 (1.14–7.12)	4 (40)	10 (14)	29.8 (3.77–235)
		Overall death	24 (51)	70 (23)	3.02 (1.79–5.10)	20 (54)	52 (22)	3.70 (2.07–6.62)	4 (40)	18 (24)	5.54 (1.26–24.4)
		Relapse	12 (26)	54 (18)	1.92 (0.98–3.76)	7 (19)	44 (19)	1.33 (0.57–3.12)	5 (50)	10 (14)	9.60 (1.84–50.1)

Abbreviations: OTR, organ transplant recipient; Tx, transplantation; HR, hazard ratio; CI, confidence interval; N, number.

^a All reported HRs refer to the contrast between OTRs, and non-transplanted cancer patients (No Tx), where the latter constitute the reference group. The regression models were adjusted for the matching factors cancer location (colon or rectum), sex, age at cancer diagnosis (±1 year), and year of cancer diagnosis, as well as region, cardiovascular comorbidity, attained level of education, and chronic dialysis at cancer diagnosis.

^b Subset of All patients.