Table 1.
Summary of clinical time-course.
| CAR-T day | +7 | +8 to +10 | +19 | +27 | +28 | +29 | +30 to +60 | +61 to +82 | +83 to +91 | +92 to +107 | +108 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALC | 40 | 20–43 | 2,030 | 1,030 | 1,400 | 920 | 40–500 | 100–170 | |||
| Events | Gr. II CRS; Gr. II ICANS |
Re-admit | Pneumonia Resp. failure |
Regained enteral access (PEG) | Hemoptysis, Sepsis, Death | ||||||
| MNT status | |||||||||||
| Immunotherapies | Toci. | IVIg | |||||||||
| Steroids | Dex. | Dex. | Dex. | Dex. | Dex. | Dex. | Dex. | Dex. | |||
| Dopaminergic therapies | Carbidopa/levodopa (C/L) | C/L | C/L | C/L Ropinirole Amantadine |
C/L Ropinirole Amantadine |
C/L Ropinirole Amantadine |
ALC , Absolute Lymphocyte Count; Dex., Dexamethasone; PEG , Percutaneous Endoscopic Gastrostomy; Toci. , Tocilizumab. Shading represents MNT symptoms, where darker shading represents more severe symptoms.