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. 2024 Apr 24;29(10):3040–3055. doi: 10.1038/s41380-024-02565-x

Fig. 3. Age-dependent increase of Aβ pathology in 3xTg and Thy1-ApoE4/C/EBPβ Tg mice.

Fig. 3

A Representative Aβ PET images showing the Aβ plaque deposition in the brains of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice at 2-, 6- and 12-month of age. The brain region was labeled with white circle. B Relative quantification of Aβ PET standard uptake value ratio (SUVR) in (A) (n = 3 mice, **p < 0.01, compared with Non Tg). C Representative of Aβ immunostaining images in the hippocampus of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice at 2-, 6- and 12-month age. Scale bar 500 μm for top panels, 20 μm for bottom panels. D and E. Co-staining of Aβ plaque with ThS D and Aβ plaque with AV45 E in brain of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice. Scale bar, 20 μm. F Levels of Aβ42, Aβ40 and ratio of Aβ42/Aβ40 in the CSF of 3xTg and Thy1-ApoE4/C/EBPβ Tg mice. (n = 3, *p < 0.05, **p < 0.01, ***p < 0.001).