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. 2024 Apr 29;29(10):3128–3140. doi: 10.1038/s41380-024-02568-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Plot of principal components PC1 and PC2, obtained from the PCA of transcriptomic data from all SCZ and CTRL lines of six time points during cortical differentiation. Each dot represents a cell line, colored by the respective time point. B Trajectory analysis of all differentially expressed genes (DEGs) from d0 to 100. Black line, CTRL group; red line, SCZ group. Data are represented as arithmetic mean ± SEM. C Heatmap visualization showing the most significant SCZ DEGs. Rows: DEGs; columns: CTRL (CTRL 1 and CTRL 2) and schizophrenia (SCZ 1 and SCZ 2) samples in d0, 7, 16, 27, 50, and 100. GO analysis highlighting the biological processes (D), molecular functions (E) and cellular components (F) of the DEGs. GO terms were generated with the ShinyGO 0.80 graphical gene-set enrichment tool [36]. d day in vitro, CTRL control, SCZ schizophrenia.