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. 2024 Apr 29;29(10):3128–3140. doi: 10.1038/s41380-024-02568-8

Fig. 3. Results of weighted gene correlation network analysis (WGCNA) and module-trait relationships.

Fig. 3

Module eigengene (ME) comparison of each module with the disease trait (A) and the six subsequent time points (B), based on Pearson’s correlation. Columns correspond to the different traits; rows correspond to the ME of each module. Upper value in each cell corresponds to Pearson’s correlation; bottom value, p-value; right panel, color scale according to correlation. C Hierarchical clustering of ME and the SCZ trait reveals higher correlation of the red cluster with SCZ and d27. Scatter plots depicting the gene significance-module membership (MM) correlation for the SCZ trait (D) and for d27 (E). Box and whiskers plots showing the relationship between the red module and the disease trait (p-value = 0.0402; F) and the timepoint d27 (p-value = 0.0353; G). GO analysis highlighting the biological processes (H) and cellular components (I) of the red module genes. GO terms were generated with the ShinyGO 0.80 graphical gene-set enrichment tool [36]. d day in vitro, CTRL control, SCZ schizophrenia, ME module eigengene. *p < 0.05.