Table 5.
Comparison of lipid profiles between alogliptin/pioglitazone combination therapy and alogliptin or pioglitazone mono add-on therapy
| Measurement | Group |
P value | ||
|---|---|---|---|---|
| Alo (n=75) | Pio (n=69) | Alo+Pio (n=70) | ||
| TC, mg/dL | ||||
| Baseline | 163.5±33.3 | 157.7±34.4 | 169.4±43.6 | 0.3751 |
| 12-week | 157.7±33.8 | 159.0±33.4 | 162.5±36.7 | 0.8200 |
| Change from baseline | –5.85±3.28 | –1.43±3.44 | –4.14±3.41 | 0.6480 |
| 24-week | 157.2±30.4 | 162.5±35.7 | 164.8±38.4 | 0.6579 |
| Change from baseline | –6.27±3.25 | 2.13±3.41 | –1.95±3.38 | 0.2050 |
| TG, mg/dL | ||||
| Baseline | 163.9±151.9 | 137.4±68.7 | 210.0±425.0 | 0.2791 |
| 12-week | 152.1±85.8 | 114.9±64.9 | 122.8±88.0 | 0.0011 |
| Change from baseline | –17.75±8.91 | –52.56±9.31 | –51.22±9.25 | 0.0094 |
| 24-week | 165.0±95.1 | 126.9±70.1 | 141.8±140.4 | 0.0015 |
| Change from baseline | –4.19±10.73 | –37.09±11.22 | –36.33±11.15 | 0.0520 |
| HDL-C, mg/dL | ||||
| Baseline | 50.3±11.0 | 52.9±13.5 | 51.8±10.6 | 0.4817 |
| 12-week | 49.0±10.1 | 58.7±13.9 | 56.0±11.5 | <0.0001 |
| Change from baseline | –1.61±0.88 | 6.08±0.92 | 4.25±0.91 | <0.0001 |
| 24-week | 48.5±11.5 | 58.9±14.6 | 58.1±14.0 | <0.0001 |
| Change from baseline | –2.06±1.08 | 6.23±1.13 | 6.34±1.12 | <0.0001 |
| LDL-C, mg/dL | ||||
| Baseline | 96.3±32.1 | 91.0±29.8 | 96.0±30.1 | 0.4464 |
| 12-week | 91.8±30.7 | 87.9±31.2 | 92.3±32.4 | 0.5869 |
| Change from baseline | –4.05±2.56 | –4.08±2.68 | –3.30±2.65 | 0.9720 |
| 24-week | 90.8±28.0 | 90.6±33.9 | 92.4±31.6 | 0.8979 |
| Change from baseline | –4.97±2.64 | –1.44±2.76 | –3.19±2.73 | 0.6520 |
| Free fatty acid, μEq/L | ||||
| Baseline | 758.6±225.9 | 746.0±250.3 | 838.9±333.5 | 0.5162 |
| 12-week | 748.9±256.9 | 591.9±249.0 | 635.9±225.6 | 0.0007 |
| Change from baseline | –24.43±26.25 | –177.21±27.39 | –164.54±27.33 | <0.0001 |
| 24-week | 726.9±250.4 | 593.3±258.1 | 652.2±280.6 | 0.0118 |
| Change from baseline | –46.87±28.79 | –176.54±30.06 | –147.02±28.99 | 0.0051 |
| Apolipoprotein B, mg/dL | ||||
| Baseline | 90.2±23.8 | 83.6±22.3 | 90.0±20.4 | 0.0462 |
| 12-week | 84.5±22.9 | 75.8±22.7 | 78.7±22.5 | 0.0016 |
| Change from baseline | –5.14±1.83 | –8.93±1.92 | –10.82±1.89 | 0.0900 |
| 24-week | 85.7±20.8 | 78.7±23.1 | 79.9±23.8 | 0.0482 |
| Change from baseline | –3.82±1.92 | –6.22±2.01 | –9.49±1.98 | 0.1200 |
Values are presented as mean±standard deviation. The Kruskal-Wallis test was used for nonparametric statistical analyses.
TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.