Table 2.
sNfL and Z-scores in PwFD vs. HC.
| PwFD, n = 50 | HC, n = 30 | p-value | |||
|---|---|---|---|---|---|
| sNfL (pg/mL)a | Z-scoreb | sNfL (pg/mL)a | Z-scoreb | ||
| all | 12.3 (13.4) | 1.12 (1.5) | 8.0 (5.5) | 0.01 (1.2) | 0.003c | <0.001d |
| Age 18 to < 51 | 9.6 (10.2) | 1.03 (1.7) | 6.2 (5.1) | 0.24 (1.3) | |
| Age 51 to < 61 | 13.1 (6.6) | 1.05 (1.3) | 9.4 (2.8) | -0.57 (0.7) | |
| Age 61 to < 70 | 35.5 (20.1) | 1.6 (0.9) | 15.6 (3.8) | 0.41 (1.3) | |
| Male | 21.9 (35.3) | 1.75 (1.5) | 7.4 (5.7) | 0.19 (1.1) | |
| Female | 11.0 (7.9) | 0.73 (1.4) | 9.3 (5.0) | -0.11 (1.2) | |
| p-value sex-diff | 0.018 c | 0.022 d | 0.935 c | 0.497d | |
PwFD: people with Fabry disease; HC: healthy controls; a: median (interquartile-range), b: mean (standard-deviation), c: Wilcoxon rank sum test, d: welch two sample t-test.