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. 2024 Oct 3;15:8578. doi: 10.1038/s41467-024-52379-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — a The experimental schema for establishing the mouse I/R injury model. The mice were intravenously administered PD146176 (10 mg/kg) or 15-HETE (0.5 mg/kg). b The 15-HETE level in the livers of each group 6 h after reperfusion (n = 4, per group). c Serum ALT and AST levels for each group 6 h after reperfusion (n = 7, per group). d Representative H&E staining, ROS staining, TUNEL staining and MPO IHC staining of liver sections from each group and quantification assessment (n = 7, per group). I/R, ischemia/reperfusion, ALT alanine aminotransferase, AST aspartate aminotransferase, HE hematoxylin and eosin, ROS reactive oxygen species, DHE dihydroethidium, TUNEL Terminal deoxynucleotidyl transferase dUTP nick end labeling, MPO cytosolic myeloperoxidase. Two-tailed t-test. Statistic data are presented as the mean ± SD, error bars represent the means of at least three independent experiments. p values are shown on the graphs, p < 0.05 was considered statistically significant. Source data are provided as a Source Data file. Figure 3a created with BioRender. com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International license (https://creativecommons.org/licenses/by-nc-nd/4.0/deed.en).