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(A to C) Production of SIV p27 antigen in stimulated (A) and resting (nonstimulated) (B) rhesus lymphocyte cultures and in MDM cultures (C). Cultures were infected with equivalent amounts of either SIVF359 (□), SIVmac239/YEnef (●), SIVmac239 (▵), or SIVmac316 (▴). (D) Production of p27 in culture supernatants of lymphocytes following cocultivation with MDM. Virus production by the parental SIV8980 (⧫) was compared to that by the end-stage variant SIVF359 (□).
