Table 3.

Genes involved in somatic variants implicated in MAFLD and HCC

Gene	Function
ARID1A, ARID2, KMT2C, SETD2, KMT2D, PBRM1, SMARCA1, SMARCA2, SMARCA4, KMT2B, DNMT3A, ASXL1, TET2	Chromatin remodeling pathway
TP53, FOXD4, CDKN2A, PTPRB, ATM, IRF2, RB1, TSC1, MDM2, ADAMTS9	Cell cycle control
CTNNB1, AXIN1, CDH8,APC	WNT/β-Catenin pathway
RPS6KA3, PREX2, PI3CA, PTEN, PTPN13, IL6ST, MET	PI3K/RAS pathway
FOXO1, CIDEB, ACVR2A, LRP1B, APOB, ALB, GPAM, PLCB4, TNRC6B, FAT4, HNF1	Lipid metabolism
TERT, NEAT1, MUC21, BRCA2, NOTCH3, HLA-F, BRCA1, TPRXL, MYD88, TSC2, NFE2L2, CAMTA1 ZNF521, PROKR2, KRAS, CSMD3, FAT3, KEAP1, SF3B1, VEGFA	Cancer development and progression
DNMT3A, ASXL1, SRSF2, RUNX1 PPM1D, CBL, CUX1, BCOR, BCORL1, GNAS, GNB1, U2AF1, TET2	Clonal hematopoiesis