Figure 6.

Adoptive transfer of HO₂-EVs induces bronchopulmonary dysplasia–like pathology. (A and B) Assessment of lung morphometry (A) showed that HO₂-EV–injected lungs had increased MLI compared with LO₂-EV–injected and control EV–injected lungs (B). (C) Immunofluorescence staining for vWF demonstrated that HO₂-EV–injected lungs had reduced vWF⁺ vessels compared with LO₂-EV–injected and control EV–injected lungs (D). n = 5 per group. Objective magnification, 20×. Scale bars, 50 μm. *P < 0.05, **P < 0.01, and ****P < 0.0001. MLI = mean linear intercept; ns = not significant; vWF = von Willebrand factor.