Table 2.
Overview of animal studies included in meta-analysis.
| First author (year) | Genotype | Type | Age, wk | Sex | n | Markers or parameters | Site | QS |
|---|---|---|---|---|---|---|---|---|
| Collagen degradation markers | ||||||||
| Kalajzic (2002) | Oim−/− | III | 4, 12, 20 | NR | 4-15 | uDPD | U | 13 |
| Oim+/− | IV | – | – | – | – | – | – | |
| Uveges (2008) | Brtl −/− | II | 9, 26 | M | 7-8 | uDPD | U | 13 |
| Chen (2014) | Col1a1Jrt/+ | IV | 5, 20 | NR | 4 | CTx1 | S | 14 |
| Grafe (2014) | Crtap−/− | VII | 8, 16 | F | 7-14 | CTx1 | S | 15 |
| Oestreich (2016) | Oim+/− | IV | 18 | NR | 15 | CTx1 | S | 14 |
| Matthews (2017) | Oim−/− | III | 8 | MF | 8 | CTx1 | S | 14 |
| Patoine (2017) | Bril−/− | V | 6, 12 | M | 4 | CTx1 | S | 15 |
| Boraschi-Diaz (2017) | Col1a1Jrt/+ | IV | 16 | MF | 4-8 | CTx1 | S | 15 |
| Jeong (2018) | Col1a2G610C+/− | IV | 18 | MF | 7-9 | CTx1 | S | 14 |
| Oim−/− | III | |||||||
| Zimmerman (2018) | Oim−/− | III | 12 | NR | 6 | CTx1 | S | 13 |
| Greene (2021) | Col1a2G610C+/− | IV | 20 | F | 10 | CTx1 | S | 15 |
| Vollersen (2021) | Wnt1+/G177C | XV | 12 | MF | 4-5 | CTX1 | S | 15 |
| Wnt1G177C/G177C | XV | – | – | – | – | – | – | |
| Bone histomorphometric parameters | ||||||||
| Morello (2006) | Ctrap−/− | VII | 12 | NR | 6 | NOc, OcS | F | 15 |
| Uveges (2008) | Brtl−/− | II | 8, 24 | M | 8-9 | NOc, OcS | F | 13 |
| Grafe (2014) | Crtap−/− | VII | 16 | F | 6 | NOc | LV | 15 |
| Chen (2014) | Col1a1Jrt/+ | V | 8 | NR | 6 | NOc, OcS | F | 14 |
| Joeng (2014) | Wnt1sw/sw | XV | 6 | NR | 5 | NOc, OcS | LV | 16 |
| Grafe (2016) | Ctrap−/− | VII | 7, 12 | F | 6 | NOc, OcS | LV | 15 |
| Patoine (2017) | Bril−/− | V | 9 | M | 4 | NOc, OcS, ES | F | 15 |
| Zimmerman (2018) | Oim−/− | III | 12 | M | 8 | NOc, OcS | LV | 13 |
| Jeong (2018) | G610C+/− | IV | 16 | MF | 3, 4 | NOc, OcS | Fr | 14 |
| Oim−/− | III | – | – | – | – | – | – | |
| Wang (2019) | Wnt1prrx1−/− | XV | 6, 12 | NR | 6 | NOc, ES | T | 14 |
| Greene (2021) | G610C+/− | IV | 10 | F | 5 | NOc | Fr | 15 |
| Vollersen (2021) | Wnt1+/G177C | XV | 4, 12, 24 | MF | 3-8 | NOc | Fr | 15 |
| Wnt1G177C/G177C | ||||||||
The genotype, represented OI type, and age of mice were extracted from the included animal studies. Sex was reported for male (M) and female (F) animals. The site for sample collection was from serum (S), urine (U), femur (Fr), tibia (T), or lumbar vertebrae (LV). Quality score (QS; out of 17 max) was assessed using the checklist (Supplementary Method 2).
Abbreviations: uDPD, urinary deoxypyridinoline; ES, eroded surface; NOc, osteoclast numbers; NR, not reported; OcS, osteoclast surface; OI, osteogenesis imperfecta.