TABLE 3.
MR analysis results in LLFS data using composite SNP from obesity/BMI related genes as IV.
| Strata | No. of Indiv. | No. of IVs | IVW Estimate (95% CI) |
IVW P value |
Weighted Median Estimate (95% CI) |
Weighted Median P value |
MR-Egger regression Intercept (95%CI) |
E-value Average (min, max) |
|---|---|---|---|---|---|---|---|---|
| White female | 232 | — | — | — | — | — | — | |
| White male | 190 | 135 | 0.192 (0.145,0.239) | 1.016E-15 | 0.243 (0.180,0.307) | 6.407E-14 | 0.442 (-0.088,0.795) | 5.26 (3.78,6.61) |
| White F + M | 422 | 47 | 0.307 (0.206,0.408) | 2.517E-9 | 0.296 (0.164,0.428) | 1.069E-5 | −2.632 (−5.115,-0.149) | 4.37 (3.67,4.68) |
Numbers in bold indicate important results.