Table 1. Diagnostic accuracy of blood eosinophil count and serum total/free IgE for adult asthma.

Biomarker	Phenotype (definition)	Mean AUC (Min. to Max.)	Study subjects	References
Blood eosinophil count	Eosinophilic asthma (sputum eosinophilia ≥ 2% or 3%)	0.79 (0.69–0.90)	Adult asthmatics	8,9,10,11,12,13,14
Serum total IgE	Eosinophilic asthma (sputum eosinophilia ≥ 2 %)	0.64	Adult asthmatics	8
	T2-high asthma (Blood eosinophil count ≥ 150 cells/uL and/or sputum eosinophilia ≥ 2% and/or FeNO ≥ 20 ppb)	0.57	Adult asthmatics	16
Serum free IgE	T2-high asthma (Blood eosinophil count ≥ 150 cells/uL and/or sputum eosinophilia ≥ 2% and/or FeNO ≥ 20 ppb)	0.73	Adult asthmatics	16

AUC, area under curve; IgE, immunoglobulin E; FeNO, fractional exhaled nitric oxide.