Table 4. Diagnostic accuracy of urine/serum LTE4 for N-ERD.

Biomarker	Phenotype	Mean AUC (Min. to Max.)	Study subjects	References
Urine LTE4	N-ERD (evaluated by HPLC-MS)	0.82 (0.80–0.83)	Adult asthmatics	56,57
	N-ERD (evaluated by ELISA)	0.87 (0.86–0.87)	Adult asthmatics	56,58
Serum LTE4	N-ERD (evaluated by UHPLC/Q-TOF MS)	0.65	Patients with N-ERD vs. those with ATA	59

N-ERD, non-steroidal anti-inflammatory drug-exacerbated respiratory disease; AUC, area under curve; HPLC, high-performance liquid chromatography; MS, mass spectrometry; ELISA, enzyme-linked immunosorbent assay; LTE4, leukotriene E4; UHPLC, ultra-high-performance liquid chromatography; Q-TOF, quadrupole time-of-flight; ATA, aspirin-tolerant asthma; HC, healthy control.