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. Author manuscript; available in PMC: 2024 Oct 4.
Published in final edited form as: Leukemia. 2020 Jun 16;34(11):2914–2924. doi: 10.1038/s41375-020-0916-8

Table 4:

Non-hematologic toxicities, grades 3–5.

CPX-351 (units/m2) Grade 3 Grade 4 Grade 5 Grade 3–5
50 75 100 50 75 100 50 75 100 All
Febrile neutropenia 1 (6) 12 (50) 6 (38) 0 0 0 0 0 0 19 (34)
Pneumonia 0 8 (33) 5 (31) 0 0 0 2 (13) 0 0 15 (27)
Sepsis - - - 2 (13) 5 (21) 2 (13) 0 0 1 (6) 10 (18)
Respiratory failure - - - 0 2 (8) 0 0 1 (4) 2 (13) 6 (11)
Skin infection 1 (6) 1 (4) 1 (6) 0 0 0 0 0 0 3 (5)
ALT/AST elevation 0 2 (8) 0 0 0 0 0 0 0 2 (4)
Bilirubin increased 0 1 (4) 1 (6) 0 0 0 0 0 0 2 (4)
Hypertension 0 0 0 0 1 (4) 1 (6) 0 0 0 2 (4)
Multi-organ failure - - - 0 0 0 0 1 (4) 1 (6) 2 (4)
Gastrointestinal hemorrhage 1 (6) 0 1 (6) 0 0 0 0 0 0 2 (4)
Acute coronary syndrome 0 1 (4) 0 0 0 0 0 0 0 1 (2)
Intracranial hemorrhage 0 0 0 0 0 1 (6) 0 0 0 1 (2)
Hypotension 0 0 1 (6) 0 0 0 0 0 0 1 (2)
Pancreatitis 0 1 (4) 0 0 0 0 0 0 0 1 (2)
Pleural effusion 0 0 0 0 1 (4) 0 0 0 0 1 (2)
Enterocolitis infectious 0 0 1 (6) 0 0 0 0 0 0 1 (2)
Joint effusion 0 1 (4) 0 0 0 0 0 0 0 1 (2)
Edema limbs 1 (6) 0 0 0 0 0 0 0 0 1 (2)