FIGURE 1.

EEG during the drowsiness and frequent seizures. This patient was recorded few days after the symptoms began. Continuous high amplitude, diffuse, irregular spike–wave complexes with higher amplitude over bilateral frontal regions, in sequences with a rhythmic‐recruiting pattern (A). Oromucosal midazolam was administered without significant changes (B). After 1 day EEG still showed continuous spike and waves discharges, EMG channels show multiple asynchronous and asymmetric myoclonic jerks over bilateral deltoids, and neck muscles. The patient was also presenting head drops typically seen in NCSE (minor motor status). Both valproate (C) and levetiracetam (D) were ineffective. He started Epydiolex CBD and after 2 days (E) and 7 days (F) there was a marked reduction of EEG epileptiform abnormalities and a resolution of NCSE. After 15 days (G) still some repetitive spikes were evident over asynchronous bilateral temporal and parietal regions. After 29 days (H), there was an improvement of background activity, further reduction in epileptiform abnormalities and the patient was persistently free from seizures.