Figure 10.

Three-dimensional representation of mimetic peptides. The (A–D) linear and (E–H) cyclic peptides are shown. Cysteine residues have been added to the C- and N-terminus to make the peptides cyclic and are indicated by ‘’. Dark lime green residues refer to the mutation added to LCDR3. (I–L) The alignments of multiple predicted structures for each linear peptide obtained by PEP-FOLD3 are also shown, where only the green peptide represents the structure directly removed from Aducanumab. Peptides with red and blue names are derived from HC and LC, respectively.