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Affinity of Aβ2–7 amino acid residues for (A–D) HC Aducanumab in (A, B) final conformations and (C, D) representative conformations, and for (E–H) LC in (E, F) FC and (G, H) RC. The depicted figure illustrates the interaction energy of Aβ2–7 residues for (A, C) Wild-HC, (E, G) Wild-LC, (B, D) Mut-HC, and (F, H) Mut-LC. The residues (of Aducanumab) in gray next to the bars are the most critical for each contact.
