Table 1.
Patient Characteristics at Baseline
| Sacubitril/Allisartan |
Olmesartan 20 mg (n = 392) |
||
|---|---|---|---|
| 240 mg (n = 391) | 480 mg (n = 393) | ||
| Male | 209 (53.5) | 198 (50.4) | 203 (51.8) |
| Age, y | 58.0 ± 8.8 | 58.6 ± 8.9 | 58.2 ± 8.5 |
| Body mass index, kg/m2 | 26.0 ± 2.5 | 25.5 ± 2.6 | 25.7 ± 2.6 |
| Blood pressure, mm Hg | |||
| Clinic systolic | 160.4 ± 6.6 | 160.8 ± 6.7 | 160.9 ± 6.9 |
| Clinic diastolic | 92.7 ± 9.1 | 91.8 ± 9.2 | 92.4 ± 8.8 |
| 24-h systolic | 146.0 ± 26.0 | 144.8 ± 25.8 | 146.2 ± 28.4 |
| 24-h diastolic | 87.6 ± 16.2 | 86.4 ± 15.8 | 87.1 ± 17.2 |
| Daytime systolic | 153.1 ± 13.5 | 152.0 ± 13.2 | 153.7 ± 13.6 |
| Daytime diastolic | 91.9 ± 9.1 | 90.7 ± 9.0 | 91.8 ± 9.0 |
| Nighttime systolic | 137.5 ± 27.1 | 136.0 ± 26.7 | 138.3 ± 29.6 |
| Nighttime diastolic | 82.4 ± 16.6 | 81.1 ± 16.0 | 82.4 ± 17.5 |
| Nondippers | 213 (59.2) | 215 (58.6) | 228 (62.3) |
| Clinic pulse rate, beat/min | 77.0 ± 12.5 | 76.5 ± 12.7 | 75.8 ± 14.0 |
| Previous antihypertensive treatment | 347 (88.8) | 359 (91.4) | 351 (89.5) |
| History of diabetes mellitus | 65 (16.6) | 55 (13.9) | 54 (13.7) |
| Current smoking | 98 (25.1) | 91 (23.2) | 98 (25.0) |
| Alcohol intake | 83 (21.2) | 66 (16.8) | 76 (19.4) |
| Blood biochemistry | |||
| Serum LDL cholesterol, mmol/L | 2.9 ± 0.8 | 3.1 ± 0.9 | 3.0 ± 0.8 |
| Serum total cholesterol, mmol/L | 4.9 ± 0.9 | 5.0 ± 1.0 | 4.9 ± 0.9 |
| Serum potassium, mmol/L | 4.2 ± 0.3 | 4.2 ± 0.3 | 4.1 ± 0.3 |
| Plasma glucose, mmol/L | 5.7 ± 0.9 | 5.7 ± 0.9 | 5.8 ± 1.0 |
| Plasma HbA1c, % | 5.8 ± 0.6 | 5.8 ± 0.6 | 5.9 ± 0.7 |
| eGFR, mL/min/1.73 m2 | 93.9 ± 12.6 | 93.9 ± 13.3 | 93.1 ± 13.0 |
Values are n (%) or mean ± SD. The P value is for the comparison between all 3 groups.
eGFR = estimated glomerular filtration rate with creatinine; HbA1c = glycosylated hemoglobin; LDL = low-density lipoprotein.