Table 4.

Summary of the statistical analysis used in the adaptive design clinical trials

Characteristic	N	%
What was the statistical method used?
Bayesian	75	23.7
Frequentist	203	64.0
Descriptive	17	5.4
Unclear	17	5.4
Not reported	5	1.6
Was there a prespecified plan for statistical handling of missing data?
Yes	30	9.5
No	155	4893
Unclear	18	5.7
Not reported	114	36.0
Was the trial stopped for superiority/non-inferiority?
Yes	19	6.0
No	210	66.2
Unclear	21	6.6
Not Applicable	67	21.1
Was the definition of superiority/non-inferiority prespecified?
Yes	53	16.8
No	197	62.3
Unclear	21	6.6
Not Applicable	45	14.2
Was the trial stopped for futility?
Yes	48	15.1
No	209	65.9
Unclear	21	6.6
Not Applicable	39	12.3
Was the definition of futility prespecified?
Yes	90	28.4
No	199	62.8
Unclear	28	8.8
Were there pre planned interim analysis?
Yes	141	44.6
No	84	26.6
Unclear	7	2.2
Not reported	84	26.6
Were the interim analysis blinded?
Yes	13	9.2
No	45	31.9
Unclear	35	24.8
Not reported	48	34
Was there a prespecified plan for statistical handling of missing data?
Yes	30	9.5
No	155	48.9
Unclear	18	5.7
Not reported	114	36.0