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Kinetics of inhibition of HIV-1 PR, G48V HIV-1 PR, and FIV PRa
| Inhibitor | Mean IC50 ± SD (nM) of:
|
|
|---|---|---|
| HIV-1 PR | FIV PR | |
| JEB [GSGVFΨ(CH2OH)VVNGL] | 160 ± 20 (60) | 5,000 ± 1,000 (3,500) |
| RQB [GSGVFΨ(CH2NH)VVNGL] | 700 ± 200 (262) | 400 ± 100 (287) |
Binding constants for the inhibition of HIV-1 PR and FIV PR by the inhibitors JEB and RQB are shown. Errors are shown as 1 standard deviation of the data from three trials. Nanomolar Ki values are given in parentheses.
