TABLE 7.
Summary of phage and peptide substratesa
| Substrate | HIV-1 PR only | FIV PR only | Both HIV-1 PR and FIV PR | Neither PRc |
|---|---|---|---|---|
| Phage | GSGIF↓LETSL | GALTN↓AVLVP | GSGIY↓TVQSL | |
| GSGVF↓VETSL | SGRIN↓VALVP | GSGVF↓VVNGL | ||
| GSGVF↓VEMPL | GAMVN↓QALVP | GSGVY↓HVSTL | ||
| GSGIM↓FESNL | SGVAL/SALVP | GSGVF↓AVTQL | ||
| GSGLF↓TEYGL | GSGVF/YTLVP | |||
| GSGVH↓VEYTL | GSGVY↓QL↓SAL | |||
| GSGNY↓FVETL | ||||
| GSGNY↓FVQGL | ||||
| GSGNY↓LVTSL | ||||
| VSQNY↓PIVQL | ||||
| GSGVY↓LATDL | ||||
| Peptideb | KSGNF↓VVNGLVK | KSGNFVVN↓GLVK | KSGVF↓VVNGLVK | KSGVN / VVNGK |
| KSGVF↓VENGLVK | KSGVF↓SVNGK | KSFVF↓VVNGLVK | KSGVQ / VVNGK | |
| KSGVF↓VQNGLVK | KSGVFHVN↓GLVK | KSGIF↓VVNGLVK | KSGVF / VNNGLVK | |
| KSGVFQVN↓GLVK | KSGVF↓HVNGK | |||
| KSGVF↓QVNGLVK | ||||
| KSGVF↓VVQGLVK | ||||
| KSGVF↓VVTGLVK |
Phage substrates were divided into the categories listed above based on an analysis of Fig. 1.
Peptide substrates were only listed in columns if at least a 100 μM concentration of the substrate was cleaved better than 30% under the conditions listed in Materials and Methods and in Table 2.
Products of the cleavage of substrates listed in the neither PR column were not detected at all.