Table 4. Demographics, clinical parameters, MnSOD allele and genotype distribution of TD and non-TD patients and healthy controls.
| Parameter |
TD
(n = 352) |
Non-TD
(n = 486) |
Controls
(n = 1150) |
Χ2 or F | p Value |
|---|---|---|---|---|---|
| Sex (male/female) | 324/28 | 379/107*** | 774/376 | 91.0 | < 0.001 |
| Age (years) | 49.3(9.2) | 47.3(9.9) *** | 43.6±12.8 | 56.63 | < 0.001 |
| Education (years) | 8.5(2.6) | 9.4(6.4) *** | 9.5±5.6 | 2.46 | 0.09 |
| Current Smoker (%) | 242(68.8%) | 292(60.1%) | 594(60.1%) | 8.99 | < 0.05 |
| Age of onset (years) | 23.7(5.2) | 23.4(5.8) | - | 0.11 | 0.71 |
| Hospitalization Times | 4.6(3.1) | 4.0(2.7) *** | - | 9.92 | < 0.01 |
| Antipsychotic dose(mg/day) | 441.2(325.7) | 482.2(435.3) | - | 2.03 | 0.19 |
| PANSS Total score | 61.4(14.6) | 59.5(15.1) | - | 2.75 | 0.06 |
| P subscore | 11.3(4.5) | 12.0(5.4) | - | 2.21 | 0.14 |
| N subscore | 24.8(7.8) | 21.8(8.4) | - | 24.46 | <0.001 |
| G subscore | 25.3(5.9) | 25.6(6.1) | - | 0.61 | 0.48 |
| MnSOD Ala-9Val polymorophism | - | - | - | - | - |
| Allele frequency (%) | - | - | - | - | - |
| Val | 606(86.1%) | 835(85.9%) | 2031(88.3%) | 4.75 | 0.09 |
| Ala | 98(13.9%) | 137(14.1%) | 269(11.7%) | - | - |
| Genotype frequency (%) | - | - | - | 9.43 | 0.051 |
| Val/Val | 258(73.3%) | 350(72.0%) | 889(77.3%) | - | - |
| Ala/Val | 90(25.6%) | 135(27.8%) | 253(22%) | - | - |
| Ala/Ala | 4(1.1%) | 1(0.2%) | 8(0.7%) | - | - |
Note: TD = tardive dyskinesia, PANSS = Positive and Negative Syndrome Scale, P = positive symptom, N = negative symptom, G = General psychopathology.
*indicates the comparison between TD and non-TD patients. *p < 0.05, **p < 0.01, ***p < 0.001.