Table 4. CREB is involved in the signaling pathways, leading to the pathogenesis and therapy of schizophrenia.
| Models | Tissue or Serum |
Expression
Level |
Regulatory Role | Disease | Targets | References |
|---|---|---|---|---|---|---|
| Schizophrenia model of MK801 rats | Hippocampus of rats | Up-regulation | Alleviated schizophrenia | Schizophrenia | CREB/BDNF/TrkB Signal | [58] |
| Juvenile MAM mice model of schizophrenia | PFC of mice | Down-regulation | Induced schizophrenia | Schizophrenia | AKT/CREB/NR2B | [102] |
| Schizophrenia model of MK801 mice | Hippocampus and mPFC of mice | Up-regulation | Alleviated schizophrenia | Schizophrenia | p-CREB, BDNF and its receptor Trk-B | [103] |
| Patients with schizophrenia | Peripheral blood of patients | Down-regulation | Induced schizophrenia | Schizophrenia | BDNF, PI3K, AKT, and CREB | [57] |
| A mouse model of schizophrenia | Hippocampus of mice | Down-regulation | Induced schizophrenia | Schizophrenia | BDNF/CREB | [104] |
| Schizophrenia model of MK801 rats | Hippocampus of rats | Up-regulation | Alleviated schizophrenia | Schizophrenia | ERK1/2-CREB | [105] |
| Primary cultures of murine cortical and hippocampal neurons | Murine neuron primary cell cultures | Down-regulation | Alleviated schizophrenia | Schizophrenia | Neurotrophin VGF and PI3K/AKT/CREB pathway | [106] |