Table 2.
Effect of dietary folate and folic acid from supplements on plasma total homocysteine, folate and cobalamin.
| Variable | Baseline | On-treatment | Treatment effect, mean percent change (95% CI) | p* | p** | p*** | |
|---|---|---|---|---|---|---|---|
| Homocysteine (μmol/l) | Folate-rich diet | 15.56 ± 3.05 | 14.18 ± 3.41 | -8.6%(-15.9;-1.2) | <0.001 | 0.008 | 0.883 |
| Folic acid from supplements | 14.32 ± 3.37 | 13.06 ± 2.77 | -8.0%(-13.3;-2.7) | ||||
| Folate (nmol/l) | Folate-rich diet | 18.89 ± 6.46 | 27.55 ± 9.48 | 52%(28.7;75.4) | <0.001 | 0.038 | 0.005 |
| Folic acid from supplements | 19.42 ± 7.53 | 34.53 ± 10.12 | 87%(68.7;106) | ||||
| Cobalamin (pmol/l) | Folate-rich diet | 401.6 ± 152.6 | 402.0 ± 180.6 | -0.94%(-7.5;5.6) | 0.350 | 0.700 | 0.358 |
| Folic acid from supplements | 405.7 ± 185.0 | 388.1 ± 140.1 | 0.15%(-5.8;6.2) |
CI: Confidence interval
* P value of ANOVA for follow up (baseline/on-treatment) comparison.
** P value of ANOVA for treatment (diet/supplements) comparison.
*** P value of ANOVA for interaction (follow up*treatment).
± values are: means ± SD