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. 2024 Oct 4;10(40):eadn8760. doi: 10.1126/sciadv.adn8760

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Fig. 8. — (i) ECs are a major source of TRAIL in the circulation. (ii) TRAIL binds and activates TRAIL-R2 to stimulate the formation of immature microvessels. (iii) EC-derived TRAIL recruits pericytes to the endothelium to form stable blood vessel networks. EC-pericyte communication is mediated by HBEGF and HBEGF receptor interactions. (iv) EC-derived TRAIL is suppressed in PAD. (v) Agonistic TRAIL-R2 mAb stimulates the formation of stable microvessels in PAD.