Table 5:
eQTL analysis results for the 3 SNPs associated with AD in múltiple GWAS studies.
| SNP/eQTL | Chr. | Position (GRCh38) | Location | mRNA | Beta | P-Value (raw) | P-Value (adjusted) | Allele tested (Minor Allele) | MAF |
|---|---|---|---|---|---|---|---|---|---|
| rs11762262 | 7 | 143410783 | 67.1 kb upstream | TAS2R41 | −0.07 | 9.45e-04 | 1.99e-02 | A | 0.21 |
| rs11771145 | 7 | 143413669 | 64.2 kb upstream | TAS2R41 | −0.15 | 2.58e-21 | 3.39e-19 | G | 0.43 |
| rs11771145 | 7 | 143413669 | 29.8 kb upstream | TAS2R60 | −0.33 | 3.26e-27 | 5.77e-25 | G | 0.43 |
| rs10228407 | 7 | 143430678 | 12.8 kb upstream | TAS2R60 | −0.31 | 7.40e-24 | 1.05e-21 | A | 0.46 |
| rs10228407 | 7 | 143430678 | 47.2 kb upstream | TAS2R41 | −0.15 | 5.11e-20 | 6.40E-18 | A | 0.46 |