TABLE 2.
IC50 values of the wild-type and mutant proteases to TL-3 and cross-resistance to saquinavir (SQV), ritonavir (RTV), and nelfinavir (NFV)
| HIV proteasea | IC50 (nM) to protease inhibitor (fold increase)b
|
|||
|---|---|---|---|---|
| TL-3 | SQV | RTV | NFV | |
| Wild type | 6 | 5 | 4 | 6 |
| V82A (1x) | 22 (4) | 12 (2) | 7 (2) | 6 (1) |
| M46I/F53L/V82A (3x) | 64 (11) | 25 (5) | 31 (8) | 24 (4) |
| L24I/M46I/F53L/L63P/V77I/V82A (6x) | 183 (30) | 47 (9) | 55 (14) | 46 (8) |
a
The 1x mutant is from passage 31, the 3x mutant is from passage 37, and the 6x mutant is from passage 56.
b
The fold increase in IC50 for a mutant protease compared to the wild-type is shown in parentheses.