Table 2.
Subgroup Differences in Periaqueductal Gray Resting State Functional Connectivity for Most Important Features Differentiating Persistent Post-Traumatic Headache Phenotypes
| PAG rsFC | Network Node | MNI Coordinates | Low Pain Coping (N=20) |
High Pain Coping (N=13) |
p-value | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| rMCC67 | Salience Network | 2 | 12 | 34 | 0.052 (0.062) | -0.019 (0.030) | <0.001 |
| rSMA68 | Sensorimotor Network | 2 | 3 | 53 | 0.050 (0.038) | -0.020 (0.055) | <0.001 |
| lSMA68 | Sensorimotor Network | −2 | 3 | 53 | 0.046 (0.043) | -0.023 (0.055) | <0.001 |
| rPCC67 | Default Mode Network | 8 | −50 | 28 | 0.060 (0.066) | -0.017 (0.036) | <0.001 |
| lM168 | Sensorimotor Network | −43 | −18 | 52 | 0.018 (0.048) | -0.016 (0.045) | <0.001 |
| rThalamus 66 | Sensorimotor Network | 22 | −24 | 0 | 0.034 (0.057) | -0.022 (0.027) | <0.001 |
| lS1 68 | Sensorimotor Network | −49 | −19 | 36 | 0.031 (0.038) | -0.037 (0.039) | <0.001 |
| lTPJ67 | Salience Network | −60 | −38 | 26 | 0.033 (0.037) | -0.034 (0.045) | <0.001 |
| lDLPFC67 | Salience Network | −38 | 40 | 28 | 0.028 (0.038) | -0.021 (0.033) | <0.001 |
| lCerebellum 66 | Sensorimotor Network | −46 | −58 | -30 | 0.034 (0.035) | -0.017 (0.032) | <0.001 |
Values are mean (SD) Fisher zr for resting sate functional connectivity (rsFC) between the periaqueductal grey (PAG) and left (l) or right (r) middle cingulate cortex (MCC), posterior parietal cortex (PCC), supplementary motor area (SMA), primary motor cortex (M1), primary sensory cortex (S1), thalamus, temporoparietal junction (TPJ), dorsolateral prefrontal cortex (dlPFC), cerebellum, and inferior parietal cortex (IPC).