FIG. 4.

K8 represses the transcription of HIV LTR in a CBP-dependent manner. (A) Transient reporter assays in 293T cells with a reporter gene, HIV LTR luciferase, and the same expression vectors. The luciferase activity of HIV LTR in the absence of the other expression vectors is normalized to a value of 1. (B) CBP relieves the repression of HIV LTR by K8 in a dose-dependent manner but does not much activate the HIV LTR promoter alone. (C) Transient reporter assays with the same reporter and expression vectors in BJAB cell lines. (D) The equivalent expression of each plasmid was verified by Western blotting.