Table 2.
New 35 migraine risk loci identified from the meta-analysis of 98,374 migraine cases and 869,160 controls.
| Locus name | RSID | Chrom osome | Position GRCh37 | Effect allele | Other allele | Effect allele frequency | Log-odds ratio | S.e. | P-value |
|---|---|---|---|---|---|---|---|---|---|
| near RUNX3 | rs71014329 | 1 | 25348950 | I | D | 0.604 | 0.034 | 0.005 | 2.57E-10 |
| ST3GAL3 | rs783302 | 1 | 44366341 | G | A | 0.878 | 0.047 | 0.008 | 1.68E-09 |
| SF3B4 | rs7544531 | 1 | 149897217 | T | C | 0.084 | 0.072 | 0.012 | 5.08E-09 |
| near DTL | rs61830764 | 1 | 212289976 | A | G | 0.382 | 0.031 | 0.006 | 3.71E-08 |
| near APLF | rs112706954 | 2 | 68819969 | G | A | 0.023 | 0.137 | 0.017 | 7.88E-16 |
| TMEM131 | rs2305142 | 2 | 98375722 | G | A | 0.322 | 0.031 | 0.005 | 1.18E-08 |
| near GPD2 | rs74482068 | 2 | 157560108 | D | I | 0.039 | 0.076 | 0.014 | 1.76E-08 |
| near RANP7 | rs11386839 | 3 | 22929430 | D | I | 0.500 | 0.029 | 0.005 | 7.68E-09 |
| ADD1 | rs10026792 | 4 | 2862190 | G | A | 0.687 | 0.032 | 0.005 | 2.79E-09 |
| EPHA5 | rs147908403 | 4 | 66362482 | C | T | 0.054 | 0.069 | 0.012 | 2.80E-09 |
| ITGA1 | rs4865540 | 5 | 52184268 | C | A | 0.820 | 0.037 | 0.007 | 1.41E-08 |
| near GLRA1 | rs372257780 | 5 | 151200938 | I | D | 0.599 | 0.033 | 0.006 | 2.27E-09 |
| KCNIP1 | rs78151838 | 5 | 170108683 | A | G | 0.905 | 0.054 | 0.010 | 1.82E-08 |
| MAML1 | rs10794701 | 5 | 179181061 | A | G | 0.119 | 0.043 | 0.008 | 3.57E-08 |
| near COX19 | rs117303395 | 7 | 1001963 | A | G | 0.019 | 0.122 | 0.022 | 4.40E-08 |
| MAD1L1 | rs10479762 | 7 | 2045351 | T | C | 0.419 | 0.029 | 0.005 | 8.01E-09 |
| ELAVL2 | rs10966033 | 9 | 23705736 | G | T | 0.617 | 0.029 | 0.005 | 2.70E-08 |
| near ZCCHC7 | rs10973207 | 9 | 37100525 | T | G | 0.187 | 0.042 | 0.007 | 1.04E-10 |
| near LMX1B | rs4358894 | 9 | 129464802 | C | G | 0.513 | 0.030 | 0.005 | 3.33E-09 |
| near DENND5A | rs34494849 | 11 | 9287030 | C | T | 0.768 | 0.034 | 0.006 | 1.17E-08 |
| near MTCH2 | rs11039324 | 11 | 47665686 | G | A | 0.601 | 0.030 | 0.005 | 9.76E-09 |
| MRE11A | rs639311 | 11 | 94205747 | C | T | 0.681 | 0.033 | 0.005 | 9.02E-10 |
| IPO8 | rs12369125 | 12 | 30807195 | A | C | 0.251 | 0.036 | 0.006 | 7.08E-10 |
| MGAT4C | rs73187675 | 12 | 86409247 | T | A | 0.193 | 0.037 | 0.006 | 6.08E-09 |
| RP11-562L8.1 | rs1957110 | 14 | 29777492 | T | C | 0.409 | 0.029 | 0.005 | 1.59E-08 |
| INSM2 | rs2296919 | 14 | 36005659 | T | C | 0.807 | 0.038 | 0.006 | 3.44E-09 |
| RPS6KA5 | rs117151272 | 14 | 91415550 | A | T | 0.026 | 0.097 | 0.018 | 3.59E-08 |
| near ONECUT1 | rs1899730 | 15 | 53166138 | T | G | 0.707 | 0.032 | 0.006 | 2.11E-08 |
| FAM174B | rs12910861 | 15 | 93218540 | C | T | 0.227 | 0.037 | 0.006 | 2.15E-09 |
| FAM65A | rs9934328 | 16 | 67573367 | C | G | 0.137 | 0.049 | 0.007 | 1.32E-11 |
| TUBG2 | rs2292750 | 17 | 40811781 | C | T | 0.452 | 0.030 | 0.005 | 3.53E-09 |
| near NRTN | rs76899991 | 19 | 5822370 | G | T | 0.963 | 0.077 | 0.014 | 2.89E-08 |
| SYMPK | rs74821481 | 19 | 46320041 | G | T | 0.678 | 0.036 | 0.005 | 4.59E-11 |
| near SERHL2 | rs141478056 | 22 | 42939927 | G | A | 0.120 | 0.046 | 0.008 | 2.23E-08 |
| near FTHL17 | rs149675702 | 23 | 31063624 | C | T | 0.945 | 0.079 | 0.014 | 4.56E-08 |
RSID = reference SNP ID, GRCh37 = Genome Reference Consortium Human Build 37, s.e. = standard error. Alleles D and I refer to deletion and insertion, respectively.