Table 3.
Variants with high (>0.9) posterior inclusion probability (PIP) and missense variants with PIP > 0.5 among the 93 high-confidence fine-map regions.
| Gene (VEP) | Predicted consequence (VEP) | RSID | Chromosome | Position GRCh37 | Effect allele | Other allele | PIP | Minor allele frequency | Log-odds ratio | S.E. | P-value | LDsource |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PHACTR1 | Intron variant | rs9349379 | 6 | 12903957 | G | A | 1.000 | 0.422 | -0.084 | 0.005 | 2.59E-60 | in-sample |
| LRP1 | Intron variant | rs11172113 | 12 | 57527283 | C | T | 1.000 | 0.404 | -0.101 | 0.005 | 7.27E-85 | in-sample |
| - | Intergenic variant | rs12445022 | 16 | 87575332 | A | G | 1.000 | 0.333 | -0.035 | 0.005 | 1.04E-10 | in-sample |
| - | Intergenic variant | rs12136718 | 1 | 156409585 | A | G | 0.999 | 0.072 | 0.046 | 0.010 | 1.95E-06 | in-sample |
| ELAVL2 | Intron variant | rs10966033 | 9 | 23705736 | T | G | 0.954 | 0.383 | -0.029 | 0.005 | 2.70E-08 | UKB-FG |
| TLX3 | 3' UTR variant | rs918472 | 5 | 170738836 | G | A | 0.932 | 0.292 | -0.029 | 0.006 | 1.95E-07 | UKB-FG |
| INPP5A | missense variant | rs1133400 | 10 | 134459388 | G | A | 0.926 | 0.198 | 0.039 | 0.006 | 5.06E-10 | UKB-FG |
| NGF | missense variant | rs6330 | 1 | 115829313 | A | G | 0.593 | 0.461 | 0.033 | 0.005 | 4.97E-11 | in-sample |