Table 2.

Pancreatic gene regulatory elements significantly enriched with somatic mutations in PDAC

a. ACRs/CREs identified in purified pancreatic acinar cells enriched for somatic mutations
Regulatory elements	ATAC-Seq	H3K4me3	H3K4me1	H3K27ac	H3K27me3	Super-enhancer
Number of elements tested	47,943	36,316	130,407	86,479	40,792	1,830
ActiveDriverWGS enriched elements	2	2	13	17	16	2
DriverPower enriched elements	1	0	2	5	0	0
b. ACRs/CREs identified in purified pancreatic ductal cells enriched for somatic mutations
Regulatory elements	ATAC-Seq	H3K4me3	H3K4me1	H3K27ac	H3K27me3	Super enhancer
Number of elements tested	28,346	47,523	145,985	115,944	48,886	2,013
ActiveDriverWGS enriched elements	1	10	11	14	11	2
DriverPower enriched elements	0	4	2	1	0	0
c. ACRs/CREs identified in normal derived pancreatic cell lines enriched for somatic mutations
Regulatory elements	ATAC-Seq	H3K4me3	H3K4me1	H3K27ac	H3K27me3	Super enhancer
Number of elements tested	110,559	202,545	341,357	289,299	33,325	2,469
ActiveDriverWGS enriched elements	5	10	15	12	11	1
DriverPower enriched elements	3	4	5	6	0	0
d. ACRs/CREs identified in PDAC cell lines enriched for somatic mutations
Regulatory elements	ATAC-Seq	H3K4me3	H3K4me1	H3K27ac	H3K27me3	Super enhancer
Number of elements tested	134,666	215,439	380,899	443,624	39,164	3,800
ActiveDriverWGS enriched elements	1	18	25	55	32	0
DriverPower enriched elements	5	8	11	17	0	1

The number of accessible chromatin regions (ACRs) histone modification marks (HMMs) and super-enhancers (SE) identified in (a) purified primary pancreatic acinar cells, (b) primary ductal cells, (c) normal derived pancreatic cell lines and (d) PDAC cells that were used for the NCSM enrichment analysis. Likewise, the number of gene regulatory elements identified as enriched for somatic mutations as per ActiveDriverWGS and DriverPower analysis are listed.