Table 2.

Isoniazid resistance-associated mutations identified in six follow-up samples

Baseline			7-wk Follow-up			23-wk Follow-up
Isoniazid Phenotype	Genotype	Detection Method	Isoniazid Phenotype	Genotype	Detection Method	Isoniazid Phenotype	Genotype	Detection Method
S	ND	ND	R	rpoB D516V, katG S315T, and inhA prom t-17 g	FluoroType MTBDR	No sample	ND	ND
R	Noncanonical katG	WGS	R	Noncanonical katG	WGS	No sample	ND	ND
R	WT	WGS	R	rpoB D516V, katG S315T, and inhA prom t-8c	FluoroType MTBDR	No sample	ND	ND
R	inhA promoter c-15t	FluoroType MTBDR	R	inhA prom c-15t	FluoroType MTBDR	No sample	ND	ND
S	ND	ND	R	Noncanonical katG	WGS	Contaminated	ND	ND
S	ND	ND	No culture	ND	ND	R	Heterodeletion of katG	WGS

Definition of abbreviations: ND = not determined; R = resistant; S = susceptible; WT = wild-type; WGS = whole-genome sequencing.