Abstract
Background:
Facial proportions and contours influence perceptions of beauty and youthfulness. In particular, the shape and definition of the midface and lower face impact the overall appearance of the face.
Methods:
This review provides anatomical evidence to support a holistic approach to facial analysis and rejuvenation that starts with assessment and treatment of the midface and lower face to create an aesthetically desirable facial balance.
Results:
The cheek and chin can be considered “anchors” or starting points within full-face treatment because of the noticeable impact of their treatment on the definition and contour of the entire face. Age-related changes in the cheek and chin affect overall facial appearance and can produce unintended facial emotional attributes such as looking tired, angry, or sad. Patients seek facial aesthetic treatment typically for a global improvement such as revitalization or genderization of facial features. Best practices in aesthetics have evolved from treatment of individual areas to a holistic paradigm that uses multimodal therapy to improve overall facial emotional attributes. Hyaluronic acid fillers are useful for volume replacement and smoothing abrupt transitions that develop with age throughout the midface, chin, and jaw. A combination of hyaluronic acid filler for volume restoration and sodium deoxycholate and/or onabotulinumtoxinA for volume reduction where appropriate may optimize lower facial contour.
Conclusions:
This review highlights the importance of facial angles and contours as well as the significance of panfacial assessments and treatment, focusing on the relationships within areas of the face, specifically the midface and lower face, to optimize results.
Takeaways
Question: What is the role of the cheeks and the chin in facial aesthetics?
Findings: This narrative review with case studies demonstrates that the cheeks and the chin contribute to the harmony and balance of facial features. They are considered the anchors of facial shape. Evaluating and treating these key areas of the face together can create a harmonious and balanced facial appearance and increase patient satisfaction and well-being.
Meaning: Attention to facial definition and contour is a foundation for achieving optimal aesthetic outcomes, and focusing on the cheeks and the chin as the pillars of facial contour and treating them appropriately may optimize results.
INTRODUCTION
Individuals desiring aesthetic treatment for facial aging or congenital deficits may identify specific areas that are bothersome (eg, periorbital wrinkles, nasolabial folds)1–4; however, they commonly expect global improvement and facial harmonization to result from treatment, including a revitalized appearance.1–5 In addition, improved understanding of the complex interplay between age-related changes in the bone, soft tissue, and skin has led to the recognition that alterations in one facial area can affect other areas.6 Data on layperson perceptions of faces with a single area treated suggest that people judge others’ facial appearances as a whole rather than focusing on individual facial features.7 Therefore, best practices in facial aesthetic medicine have evolved from the treatment of individual areas to a holistic paradigm that considers the entire face and uses multimodal therapy to provide harmony and balance among facial features (ie, a panfacial treatment approach).8–10
Facial aesthetic ideals that individuals may be seeking to achieve or restore with panfacial treatment include ideal facial contours, symmetry, balance, youthfulness, averageness (prototypicality), and sexual dimorphism (alignment with perceived gender-specific features).11–13 For example, an inverted triangle, with wide, full cheeks as the upper vertices and a defined chin as the lower apex, is seen as emblematic of facial youthfulness and beauty.2,14–16 Aesthetic literature also refers to the “ogee” curve—a concave arc flowing into a convex arc, forming an S shape—as the ideal contour of the cheek in profile, with the hollow of the midcheek leading into a defined malar region or cheekbone.15,17 Similarly, the angle of the ramus of the mandible described by Liew and Dart18 is globally recognized as an area in the lower face that impacts attractiveness.16 Because the cheeks and chin are important to facial contouring and form the vertices of the inverted “triangle of youth,” they are key aspects in a panfacial treatment approach.15 This review provides anatomical evidence to support a panfacial approach to facial analysis and rejuvenation that prioritizes the treatment of the cheeks and chin. It describes a unified volume and contour restoration process with practical clinical guidance for treating the cheeks and the chin as well as illustrative case study examples.
IMPORTANCE OF THE CHEEK AND CHIN IN FACIAL AESTHETICS
Facial aesthetic ideals and preferences often relate to the shape and definition of the midface and lower face and may vary by gender, race, ethnicity, or culture.5,12,19,20 For example, individuals of Asian descent may consider oval-shaped faces more attractive than faces with a broader lower jaw.21 Cultural or ethnic ideal facial proportions may reflect differences in interzygomatic and intergonial width, midfacial height, and extent of chin projection and lip fullness.22–24 Optimal facial proportions and contours also differ by gender.25 The youthful feminine cheek is higher, fuller, and more projected in all dimensions than the masculine cheek.20 The feminine apex of the cheek is more lateral and well defined, tapering to a narrower, less-prominent jaw and a smaller, less-projected chin, forming a heart shape.14,26 Masculine faces are characterized by a flatter anteromedial cheek and a more medial and subtly defined cheek apex.16 The ogee curve is also flatter in its lower concave region, ideally leading to a squarer, broader, more muscular jaw and a wider, squarer, and more projected chin.12,27
By contrast, the aged face is typified by depletion of volume caused by atrophy and descent of midfacial fat and soft tissue, which overlie the jawline and lead to blunted definition of the chin and jaw.28–30 The aged face also exhibits a loss of homogeneity in aesthetic subunits and a decline in skin tone and texture.30 Desired contours, symmetry, and balance deteriorate as age-related changes in facial elements develop at differing rates.29,30 The desirable facial “triangle” begins to overturn as deep medial and buccal fat pads in the midface atrophy and nasolabial and superficial cheek fat descend (Fig. 1).2,15,16,30,31,33–35 Additional loss of support from maxillary recession and attenuation of retaining ligaments exacerbates the downward shift.29,34,36 The resultant loss of cheek projection flattens the ogee curve; the cheeks seem hollow, the nasolabial fold and jowls become more prominent, and the skin slackens (Fig. 2).6,16,28–30,32,33
Fig. 1.
The “triangle of youth” is a paradigm for facial proportions and contours associated with youth and beauty. A, The upside-down triangle signifies a full and wide midface at the base of the eyes spanning from either side of the cheeks and leading down to a defined chin angle as emblematic of the youthful face.15 B-C, As aging progresses, the lower face widens from the descent of facial skin, fat, and muscle, reversing the triangle.2,16,31
Fig. 2.
Contour of the lower face. Changes in facial contour that develop with aging, as illustrated by the midface and lower face, (A) youthful and (B) aged. The youthful cheek exhibits fullness and a smooth, round, uniform shape. The junction from the lower lid to the cheek has a fluid contour with a concave shape. In contrast, the aged cheek is characterized by the formation of grooves resulting from descent of cheek skin, muscle, and fat, revealing segmentation between lid-cheek (brown), malar (red), and nasolabial (yellow) segments. Ogee curve restoration is a typical treatment goal.16,28–30 The youthful lower face is characterized by fixed underlying fat pads, including the anterior of the malar (red) and nasolabial (yellow) fat; firm, elastic skin; and a well-defined jawline (black dashed line). In the aged lower face, jowls and labiomandibular folds, absent in youth, emerge. Jowls form as the skin loses elasticity and the inferior jowl fat pad (dark blue) descends beneath the jawline. Labiomandibular folds arise from the distension of weakened masseteric ligaments and inferior displacement of buccal fat (medium blue).32
The contour of the lower face also deteriorates with facial aging (Fig. 2). A deep chin fat compartment below the mentalis muscle atrophies, leading to labiomental creases.33 Mandibular resorption contributes to loss of projection of the chin.37 The jawline loses definition with the descending tissue from above, mandibular volume loss, and development of the anterior mandibular groove and prejowl sulcus.30,37 Redistribution of the superior and inferior jowl fat compartments and weakening of the mandibular septum holding these compartments in place cause the jowls to sag.6,30 Stretching of retaining ligaments may cause indentations in the skin, and contraction of the platysma muscle may exacerbate soft-tissue descent and blur the boundary between the jawline and neck.6,30,38 Lines and creases also develop in the skin related to habitual facial expressions, dynamic muscle movement, and aging-related muscle hypertonia.31
These changes in soft tissue, muscles, fat compartments, and bones can result in unintentional emotional facial attributes (eg, looking tired, angry, or sad).8 For example, chin volume loss, descending oral commissures, and prominent labiomandibular folds (“marionette lines”) may produce an overall look of sadness.4,30,31,39 Hyperactivity of the depressor anguli oris and platysma muscles, loss of cheek support and descent of buccal fat, and downward pull of jowl fat may further exacerbate this effect.30,32,40 Downturned corners of the mouth may impart an angry expression, whereas loss of volume in the cheeks may give an impression of tiredness.4,8,41
PANFACIAL APPROACH TO FACIAL REJUVENATION
Key concepts in the panfacial approach to facial aesthetic treatment are shown in Table 1.4,5,8,9,24,41–44 Patients receive a pretreatment assessment that considers the entire face5,9,45 and identifies the relevant contributing tissues (ie, skin, muscle, fat, bone).8 Initial patient consultations should begin with identifying patients’ aesthetic concerns and objectives for facial rejuvenation4,8,24 and informing the patient that addressing a single area can lead to inadequate results.42 For example, treatment of the prejowl region alone could give the impression of a wider chin.46 It is important to encourage patients to recognize that all parts of the face contribute to its emotional attributes; therefore, a panfacial approach may improve these attributes.8
Table 1.
Panfacial Approach to Facial Rejuvenation for the Clinician
| Step | Goal | Guiding Question | Practice Recommendation |
|---|---|---|---|
| 1. Discuss individual patient goals | Determine why the patient is seeking treatment | For what concerns is the patient seeking treatment? Does the patient seek to improve the overall emotional messaging of the face (eg, a tired or an angry appearance)? |
Use the answers to these questions to develop a specific education plan in step 2 If a patient is seeking treatment for a specific area, discuss how that area may influence other areas42 If a patient is seeking to improve overall facial messaging, explain how specific areas may be contributing to unintended emotional attributes4,8,41 |
| 2. Educate the patient on panfacial treatment | Inform the patient about the interrelated nature of facial expression of emotion and/or aging Build patient trust in clinician assessment |
Is the patient seeking treatment in an area of the face that will affect other areas? What are the patient’s aesthetic goals? What is the patient’s background (eg, older age group, ethnicity/race, transgender/nonbinary)? |
Use these answers to inform the treatment plan developed in step 3 If the patient is seeking treatment for a specific area, include other potentially affected facial areas in the treatment plan Ensure the treatment plan addresses individualized concerns that may arise from the patient’s unique background5 |
| 3. Develop a panfacial treatment plan | Determine which regions of the face will be treated Determine the order of treatment |
What areas require treatment to achieve the patient’s goals? Is the patient unsure of specific areas for treatment? |
If the treatment plan will include multiple regions of the face, treat the midface before the upper and lower regions of the face24 Once the midface is treated, reassess appearance of the lower face and other areas to help ensure harmonious, balanced aesthetic results9,43,44 If the patient is unsure of which areas to treat, recommend universally desired treatments such as adding volume to the cheek area5,8 |
Treatment planning should involve individualized panfacial assessment and consideration of demographically based preferences that may underlie the patient’s concerns.5 For example, panfacial restoration in younger patients may focus on addressing congenital or acquired disharmonies such as lines that were present since childhood or caused by injury, whereas in older patients, age-appropriate restoration of facial contours may be the predominant goal.5 When treating patients from diverse ethnicities, clinicians should be mindful of significant geographic and cultural variations in treatment approaches,5 and they should consider whether individuals are seeking feminization, masculinization, or gender neutralization of facial features.26,47 Professionals can guide discussions with patients about panfacial treatment by noting commonalities across age, ethnicity, or gender, such as the midface being one of the first facial areas to show signs of aging, and the overall improvement that adding volume to this area may achieve.5,8
Panfacial treatment can include a number of surgical chin or cheek aesthetic procedures to improve facial contour, such as genioplasty and augmentation using autologous or alloplastic implants; however, surgery may not be practical or appropriate for all individuals.42 Nonsurgical treatments, such as injectable facial fillers or neurotoxins, are less-invasive, nonpermanent, and increasingly popular among those seeking aesthetic correction of the cheeks and the chin.5,26,42
The US HARMONY study demonstrated that a comprehensive, minimally invasive, multimodal, panfacial treatment approach resulted in significant improvement in patient satisfaction with facial appearance and psychosocial impacts.9,48,49 The US HARMONY study was a rater-blinded study that evaluated patient satisfaction and aesthetic impact of a combination of fillers (VYC-20L, HYC-24L, and HYC-24L+) for facial volumization and treatment of lines and folds; onabotulinumtoxinA for treatment of upper facial rhytids; and bimatoprost for treatment of eyelash hypotrichosis.9 Nearly all (99%) treated patients (n = 100) rated themselves as improved or much improved on the Global Aesthetic Improvement Scale. Patients reported that they were “very satisfied” with facial symmetry, balance, and proportions and reported looking fresh and rested. Furthermore, the authors emphasized that a panfacial approach to assessment and treatment may help prevent potential overtreatment of individual areas.9
In a 2019 post hoc analysis of the US HARMONY study, respondents aged 18 to 65 years viewed standardized baseline and 4-month posttreatment images of patients from US HARMONY and completed an online questionnaire indicating their perceptions of these patients.50 Patients in posttreatment images were rated as more socially adept, friendly, successful, healthy, approachable, and educated versus patients in pretreatment images.50 Therefore, panfacial aesthetic treatment had quantifiable positive impacts on social perceptions beyond age and attractiveness. Aesthetic treatments have also resulted in positive perceptions of the patient’s appearance by significant others.51
Initiating Panfacial Treatment with the Cheek and the Chin
Cheek and chin rejuvenation has demonstrated a noticeable impact on the definition and contour of the entire face, providing an anatomical rationale to begin panfacial treatment with enhancing facial shape, the anchors of which are the cheeks and the chin.3,8,15,52 Evidence supports volumizing with hyaluronic acid (HA) filler treatment in the cheeks and chin for greater patient satisfaction and superior clinical outcomes. HA fillers are used to replace volume and smooth the abrupt transitions that develop with age throughout the midface, chin, and jaw.33,46,52 US HARMONY study investigators and other researchers have recommended treating the midface first when indicated to better determine the filler requirements and appropriate products for the full face and to achieve a natural-looking effect.45,46 Facial reshaping may involve midface volume restoration as well as lower facial volume reduction using deoxycholic acid (for submental fat) or neurotoxin injections (for masseter muscle prominence or for elongating the chin or correcting a dimpled or misshapen chin).53,54
Favorable outcomes with injectable aesthetic treatments depend on many factors, including patient selection and safety profile. The cost of injectable treatments may not be feasible for all individuals.19 Additionally, injectable facial treatments using HA, neurotoxins, or deoxycholic acid typically involve temporary side effects at the site of injection, which may include bruising, swelling, redness, pain, firmness, and tenderness.9,55 Safety considerations and patient selection criteria for injectable treatments have been described in greater detail elsewhere.4,56–60 Guidance on treating the midface and lower face follows, and locations of commonly treated facial regions are shown in Figure 3.
Fig. 3.
Anatomical landmarks for cheek and chin/jaw rejuvenation.
Midface
The youthful midface has a rounded cheek with smooth transitions to adjacent areas.24,28 On posterolateral view, the ideal projection of the cheek ogee curve is similar to that of the chin.17 Midfacial rejuvenation should restore the fullness of the cheek contour and its smooth transitions to the lower lid, nose, nasolabial, and lateral facial regions without abrupt demarcation of these as distinct regions.24 Specific HA fillers may be used to correct radial cheek lines.7,61 In patients with midface volume deficit, HA fillers can improve midface volume,55,62 with high rates of patient satisfaction regarding symmetry, smoothness, attractiveness, and contour of the cheeks.55
Key Treatment Principles
Clinical data support injecting the cheeks first during HA filler treatment sessions that address multiple facial areas.4,63,64 The aesthetic goals of treating the cheek with HA fillers include volume restoration, projection, and three-dimensional contouring.55,62 HA filler characteristics contributing to successful treatment of the cheek region include medium to high G′ (elasticity) and cohesivity to provide appropriate lift capacity, resistance to shearing and compressive forces, and the capacity to adapt naturally to the dynamic muscle activity in this area.31,65 Injection of HA filler with high G′ and high cohesivity into the deep supraperiosteal region is recommended to restore foundational support to soft tissue.43,44 This approach produces a more natural outcome by avoiding the creation of a visible mass of filler gel under the surface of the skin.43 HA filler with low G′, low cohesivity, and low water uptake may be injected more superficially to improve skin texture, smoothness, fine lines, and hydration.31,43,65–67 Fillers with moderate G′ and cohesivity are suitable for injection to replace volume from descended or atrophied malar fat pads.43 Because anteromalar, submalar, and posteromalar volume loss contribute to the formation of infraorbital hollows and nasolabial folds, before treating infraorbital hollows and nasolabial folds, it is prudent to assess volume correction in these areas after administering malar and perimalar injections.44,64,68 One pivotal clinical trial found improvements in untreated areas of the face, such as infraorbital hollows (referred to as tear troughs in the study) and nasolabial folds, following treatment of the midface with an HA injectable gel (VYC-20L; Allergan Aesthetics, an AbbVie Company, Irvine, Calif.).64 The percentage of patients satisfied with the appearance of their infraorbital hollows increased from 47.2% (110 of 233) at baseline to 84.7% (177 of 209) at 6 months after cheek augmentation, and the percentage of patients who reported being satisfied with their nasolabial folds increased from 31.2% (73 of 234) at baseline to 73.6% (153 of 208) at 6 months after treatment. A multicenter, evaluator-blind, randomized, within-subject, controlled study of cheek augmentation with facial fillers in adults with a moderate to severe midface volume deficit found more than 50-point increases in FACE-Q Satisfaction with Cheeks scores at months 1 and 3 after treatment compared with baseline.55 FACE-Q Satisfaction with Cheeks data also demonstrated posttreatment satisfaction rates of more than 90% for cheek symmetry.
Lower Face
The lower one-third of the face is key to sexual dimorphism and has proportionally greater height in men than in women.20,69 The width of the chin is equivalent to that of the mouth in men and to the medial intercanthal distance in women. Chin projection should be approximately in line with the lower lip in men and 1–2 mm behind the lower lip in women.46 In both sexes, a well-defined inferior mandibular border from mentum to angle with no jowl overhang and a chin and jawline clearly defined as distinct regions are desirable.70 Enhanced chin projection may improve the appearance of adjacent areas such as jowling or signs of aging in the neck.71,72 In one retrospective study, 20 days after receiving treatment with an HA injectable gel alone (VYC-25L; Allergan Aesthetics, an AbbVie Company, Irvine, Calif.) in the chin, jawline, marionette lines, and labiomental sulcus, 97% of patients rated their facial appearance as “much improved” or “very much improved” on the Global Aesthetic Improvement Scale.72 The authors noted that redefinition of the jawline using an HA filler is a “potentially high-impact approach” for patients across various economic and biologic circumstances.72
Treatment of the chin with HA filler is a safe, effective, viable alternative to surgical chin augmentation.72–74 Although surgical augmentation was long considered the gold standard for chin correction, a skilled injector can improve all dimensions of the chin using HA fillers and simultaneously address lateral oral commissures, mental crease, marionette lines, and prejowl and postjowl sulci.71,75 A randomized controlled trial of 192 adults with chin retrusion demonstrated that an HA filler for chin volume restoration (VYC-20L) safely and significantly improved response on a validated chin retrusion scale at 6 months after treatment, with high rates of patient satisfaction and continued treatment benefit at 1 year.74 In another study, an HA filler (VYC-25L) applied to the chin and jaw to treat patients with chin retrusion significantly improved glabella–subnasale–pogonion facial angle and increased patient satisfaction with the chin, lower face, and jawline, with physical improvements and patient satisfaction maintained beyond 18 months.75,76
HA fillers have also been safely and effectively used to restore jawline definition. A prospective, evaluator-blinded, multicenter, randomized study in approximately 200 patients with moderate or severe loss of jawline definition demonstrated the safety and effectiveness of VYC-25L injections along the jawline and chin for restoring loss of jawline definition, with significantly higher Allergan Loss of Jawline Definition Scale responder rates versus untreated control at month 6, high participant satisfaction, and treatment benefit lasting at least a year.77
Injectable treatments that reduce volume may also be an important aspect of lower facial reshaping. The Canada HARMONY study evaluated a combination of HA fillers, onabotulinumtoxinA, deoxycholic acid to reduce submental fullness, and a daily regimen of medical-grade skincare products. All patients (n = 58) had statistically significant (P < 0.0001) improvement from baseline at the final visit on the validated FACE-Q Satisfaction with Facial Appearance Scale (primary endpoint), with a mean score increase of 30.3.49 OnabotulinumtoxinA injection is widely used for reducing excess masseter muscle volume that may result in a square-shaped face; it is injected into the masseter muscles to diminish lower facial bulk and reshape the face to the desired inverted triangle.78 Injections of deoxycholic acid or onabotulinumtoxinA have been used successfully to improve the shape, projection, and contour of the chin.53,54
Key Treatment Principles
The aesthetic goals of treating the chin with HA fillers include improvement in proportion (widening for masculinization and tapering toward the center or pogonion for feminization), projection, and contouring.76 Improvements should be seen in the lateral oblique profile view.46,71,79 The HA fillers most appropriate for the chin will have high G′ and medium to high cohesivity for greater lift capacity and contour enhancement and to resist deformation. Resistance to compressive forces is necessary to accommodate the high compression and tight skin and muscle over the bone that characterize this region.43,65 Recommended injection areas to improve chin projection and to augment chin length are the pogonion and the menton area, respectively.46 The HA fillers should be injected in the prejowl region above the mandibular line and deeply into the mentalis muscle to project and lengthen. To complement this approach, HA may be injected more superficially in the same region to smoothen the area.46 The recommended injection areas to restore jawline definition are the chin, prejowl area, and the mandibular line, angle, and ramus.46 The inferior and superior limits of the injection area are, respectively, the mandibular border and the horizontal area approximately 1.5 cm above the mandibular border.46 When injecting along the jawline, it is critical to locate the facial artery at the antegonial notch (about 1 cm from anterior masseter muscles) and inject away from the artery exit, in the preperiosteal or subdermal plane.4,44 Injection depth for the chin is subdermal, supraperiosteal, or a combination of both.4,72
UNIFIED APPROACH TO CHEEK AND CHIN REJUVENATION: CASE EXAMPLES
The treatments that may be applied to the cheek and chin and the potential outcomes of treatment are demonstrated by the case examples presented in Figure 4 and Supplemental Digital Contents 1–3. (See figure, Supplemental Digital Content 1, which shows a case example of a Latino man aged 43 years, http://links.lww.com/PRSGO/D546) (See figure, Supplemental Digital Content 2, which shows a case example of a White woman aged 60 years, http://links.lww.com/PRSGO/D547.) (See figure, Supplemental Digital Content 3, which shows a case example of a White woman aged 47 years, http://links.lww.com/PRSGO/D548.) Example videos on treatment of the cheek and chin are shown in Videos 1–3. (See Videos 1 and 2 [online], which show a case example of a Hispanic woman aged 25 years treated for aesthetic concerns of the midface and lower face.) (See Video 3 [online], which shows a case example of a Latino man aged 43 years treated for aesthetic concerns of the midface and lower face.)
Fig. 4.
Potential outcomes of cheek and chin treatment. Case example of a Hispanic woman aged 25 years (A–D) before and (E–H) 2 weeks after treatment for aesthetic concerns of the midface and lower face. The patient had chin retrusion with a lack of lip–chin transition, an asymmetric lower face with a smaller angle of the mandible on the right side, and a hypoplastic midface. Fillers were administered as follows: each cheek, VYC-20L HA injectable gel 2 mL (Allergan Aesthetics, an AbbVie Company, Irvine, Calif.); chin, VYC-25L HA injectable gel 2.3 mL (Allergan Aesthetics, an AbbVie Company); right jawline, VYC-25L 0.8 mL; and left jawline, VYC-25L 2 mL. Posttreatment results demonstrated improved facial balance and harmony through better vertical alignment of the forehead, nose, and chin; improvement in the facial profile; improved midface projection; and improved lower facial symmetry and definition. Photographs courtesy of A. Moradi, M.D.
Video 1. which show a case example of a Hispanic woman aged 25 years treated for aesthetic concerns of the midface and lower face.
Video 2. which show a case example of a Hispanic woman aged 25 years treated for aesthetic concerns of the midface and lower face.
Video 3. which shows a case example of a Latino man aged 43 years treated for aesthetic concerns of the midface and lower face.
CONCLUSIONS
A harmonious and balanced facial appearance is the foundation of achieving optimal aesthetic outcomes that can lead to high rates of patient satisfaction and positive psychosocial outcomes. This review highlights the importance of facial angles and contours and the significance of full facial assessments and treatment, focusing on the relationships between areas of the face, specifically the cheeks and the chin, as the pillars of facial contour whose treatment may optimize results. This information aims to provide education for clinicians that encourages holistic assessment and treatment of interrelated facial areas in their patients.
DISCLOSURES
Dr. Moradi is a consultant, clinical research investigator, faculty member, and advisor for AbbVie; a consultant, advisor, steering committee member, European summit expert, and clinical research investigator for Galderma; consultant, advisor, and clinical research investigator for SkinMedica; consultant, speaker, and clinical research investigator for Alastin; honorarium recipient for Evolus; clinical research investigator for Recros Medica; and clinical research investigator, consultant, and stockholder for Glo Pharma; advisor and consultant for Teoxane; clinical research investigator for Symatese; and sponsored publication author for IQVIA/Endo. Dr. Montes is a speaker, trainer, clinical trial investigator, and advisor for AbbVie. Dr. Humphrey is a speaker, consultant, and investigator for AbbVie. Dr. Grunebaum is a consultant and researcher for AbbVie and Galderma. Dr. Bertossi receives research grants for investigator-initiated and sponsored trials and is a speaker and trainer for AbbVie. Dr. Dimitrijevic is a full-time employee of AbbVie and owns AbbVie stock. Dr. Sangha is a full-time employee of AbbVie.
Allergan Aesthetics, an AbbVie Company, funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication. All authors had access to relevant data and participated in the drafting, review, and approval of this publication. No honoraria or payments were made for authorship. Medical writing support was provided to the authors by Regina Kelly, MA, of Peloton Advantage, LLC, an OPEN Health company, and funded by Allergan Aesthetics, an AbbVie Company.
Supplementary Material
Footnotes
Published online 4 October 2024.
Disclosure statements are at the end of this article, following the correspondence information.
Related Digital Media are available in the full-text version of the article on www.PRSGlobalOpen.com.
REFERENCES
- 1.Sobanko JF, Taglienti AJ, Wilson AJ, et al. Motivations for seeking minimally invasive cosmetic procedures in an academic outpatient setting. Aesthet Surg J. 2015;35:1014–1020. [DOI] [PubMed] [Google Scholar]
- 2.Narurkar V, Shamban A, Sissins P, et al. Facial treatment preferences in aesthetically aware women. Dermatol Surg. 2015;41:S153–S160. [DOI] [PubMed] [Google Scholar]
- 3.de Maio M. The 7-point shape and the 9-point shape: an innovative non-surgical approach to improve the facial shape. Facial Plast Surg. 2022;38:102–110. [DOI] [PubMed] [Google Scholar]
- 4.de Maio M, Chatrath V, Hart S, et al. Multi-dimensional aesthetic scan assessment (MD ASA): initial experience with a novel consultation, facial assessment, and treatment planning tool. J Cosmet Dermatol. 2021;20:2069–2082. [DOI] [PubMed] [Google Scholar]
- 5.Sundaram H, Liew S, Signorini M, et al. ; Global Aesthetics Consensus Group. Global aesthetics consensus: hyaluronic acid fillers and botulinum toxin type A—recommendations for combined treatment and optimizing outcomes in diverse patient populations. Plast Reconstr Surg. 2016;137:1410–1423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Coleman SR, Grover R. The anatomy of the aging face: volume loss and changes in 3-dimensional topography. Aesthet Surg J. 2006;26:S4–S9. [DOI] [PubMed] [Google Scholar]
- 7.Ogilvie P, Fink B, Leys C, et al. Improvement of radial cheek lines with hyaluronic acid-based dermal filler VYC-17.5L: results of the BEAM study. Dermatol Surg. 2020;46:376–385. [DOI] [PubMed] [Google Scholar]
- 8.Lipko-Godlewska S, Bolanča Z, Kalinová L, et al. Whole-face approach with hyaluronic acid fillers. Clin Cosmet Investig Dermatol. 2021;14:169–178. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Weinkle SH, Werschler WP, Teller CF, et al. Impact of comprehensive, minimally invasive, multimodal aesthetic treatment on satisfaction with facial appearance: the HARMONY study. Aesthet Surg J. 2018;38:540–556. [DOI] [PubMed] [Google Scholar]
- 10.Jones D. Volumizing the face with soft tissue fillers. Clin Plast Surg. 2011;38:379–390, v. [DOI] [PubMed] [Google Scholar]
- 11.Thomas JR, Dixon TK. A global perspective of beauty in a multicultural world. JAMA Facial Plast Surg. 2016;18:7–8. [DOI] [PubMed] [Google Scholar]
- 12.Keaney TC, Anolik R, Braz A, et al. The male aesthetic patient: facial anatomy, concepts of attractiveness, and treatment patterns. J Drugs Dermatol. 2018;17:19–28. [PubMed] [Google Scholar]
- 13.Marquardt SR, Dr. Stephen R. Marquardt on the Golden Decagon and human facial beauty. Interview by Dr. Gottlieb. J Clin Orthod. 2002;36:339–347. [PubMed] [Google Scholar]
- 14.Morrison SD, Vyas KS, Motakef S, et al. Facial feminization: systematic review of the literature. Plast Reconstr Surg. 2016;137:1759–1770. [DOI] [PubMed] [Google Scholar]
- 15.Jones D. Injectable Fillers: Principles and Practice. Oxford, UK: Wiley-Blackwell; 2010. [Google Scholar]
- 16.Swift A, Remington K. BeautiPHIcation: a global approach to facial beauty. Clin Plast Surg. 2011;38:347–377, v. [DOI] [PubMed] [Google Scholar]
- 17.Muhn C, Rosen N, Solish N, et al. The evolving role of hyaluronic acid fillers for facial volume restoration and contouring: a Canadian overview. Clin Cosmet Investig Dermatol. 2012;5:147–158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 18.Liew S, Dart A. Nonsurgical reshaping of the lower face. Aesthet Surg J. 2008;28:251–257. [DOI] [PubMed] [Google Scholar]
- 19.Boyd C, Chiu A, Montes JR, et al. Differential facial aesthetic treatment considerations for skin of color populations: African American, Asian, and Hispanic [poster]. Annual Meeting of the American Academy of Dermatology; February 16-20, 2018; San Diego, CA; 1: s66. [Google Scholar]
- 20.de Maio M. Ethnic and gender considerations in the use of facial injectables: male patients. Plast Reconstr Surg. 2015;136:40S–43S. [DOI] [PubMed] [Google Scholar]
- 21.Chang CS, Lin S, Wallace CG, et al. Masseter muscle volume changes evaluated by 3-dimensional computed tomography after repeated botulinum toxin A injections in patients with square facial morphology. Ann Plast Surg. 2019;82:S29–S32. [DOI] [PubMed] [Google Scholar]
- 22.Veerala G, Gandikota CS, Yadagiri PK, et al. Marquardt’s facial golden decagon mask and its fitness with South Indian facial traits. J Clin Diagnost Res. 2016;10:ZC49–ZC52. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 23.Alam MK, Mohd Noor NF, Basri R, et al. Multiracial facial golden ratio and evaluation of facial appearance. PLoS One. 2015;10:e0142914. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24.Bueller H. Ideal facial relationships and goals. Facial Plast Surg. 2018;34:458–465. [DOI] [PubMed] [Google Scholar]
- 25.Farhadian JA, Bloom BS, Brauer JA. Male aesthetics: a review of facial anatomy and pertinent clinical implications. J Drugs Dermatol. 2015;14:1029–1034. [PubMed] [Google Scholar]
- 26.De Boulle K, Furuyama N, Heydenrych I, et al. Considerations for the use of minimally invasive aesthetic procedures for facial remodeling in transgender individuals. Clin Cosmet Investig Dermatol. 2021;14:513–525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 27.Rossi AM. Men’s aesthetic dermatology. Semin Cutan Med Surg. 2014;33:188–197. [DOI] [PubMed] [Google Scholar]
- 28.Mendelson BC, Jacobson SR. Surgical anatomy of the midcheek: facial layers, spaces, and the midcheek segments. Clin Plast Surg. 2008;35:395–404; discussion 393. [DOI] [PubMed] [Google Scholar]
- 29.Rohrich RJ, Avashia YJ, Savetsky IL. Prediction of facial aging using the facial fat compartments. Plast Reconstr Surg. 2021;147:38S–42S. [DOI] [PubMed] [Google Scholar]
- 30.Swift A, Liew S, Weinkle S, et al. The facial aging process from the “inside out.” Aesthet Surg J. 2021;41:1107–1119. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 31.Michaud T, Gassia V, Belhaouari L. Facial dynamics and emotional expressions in facial aging treatments. J Cosmet Dermatol. 2015;14:9–21. [DOI] [PubMed] [Google Scholar]
- 32.Mendelson B, Wong CH. Anatomy of the aging face. In: Neligan PC, ed. Plastic Surgery. Toronto: Elsevier; 2013:78–92. [Google Scholar]
- 33.Rohrich RJ, Pessa JE, Ristow B. The youthful cheek and the deep medial fat compartment. Plast Reconstr Surg. 2008;121:2107–2112. [DOI] [PubMed] [Google Scholar]
- 34.Wulc AE, Sharma P, Czyz CN. The anatomic basis of midfacial aging. In: Hartstein ME, Wulc AE, Holck DE, eds. Midfacial Rejuvenation. New York, N.Y.: Springer New York; 2012:15–29. [Google Scholar]
- 35.Humphrey S, Beleznay K, Fitzgerald R. Combination therapy in midfacial rejuvenation. Dermatol Surg. 2016;42:S83–S88. [DOI] [PubMed] [Google Scholar]
- 36.Richard MJ, Morris C, Deen BF, et al. Analysis of the anatomic changes of the aging facial skeleton using computer-assisted tomography. Ophthal Plast Reconstr Surg. 2009;25:382–386. [DOI] [PubMed] [Google Scholar]
- 37.Romo T, Yalamanchili H, Sclafani AP. Chin and prejowl augmentation in the management of the aging jawline. Facial Plast Surg. 2005;21:38–46. [DOI] [PubMed] [Google Scholar]
- 38.Pilsl U, Anderhuber F. The chin and adjacent fat compartments. Dermatol Surg. 2010;36:214–218. [DOI] [PubMed] [Google Scholar]
- 39.Fitzgerald R. Contemporary concepts in brow and eyelid aging. Clin Plast Surg. 2013;40:21–42. [DOI] [PubMed] [Google Scholar]
- 40.Coleman KR, Carruthers J. Combination therapy with BOTOX and fillers: the new rejuvenation paradigm. Dermatol Ther. 2006;19:177–188. [DOI] [PubMed] [Google Scholar]
- 41.van der Sluis N, Gülbitti HA, van Dongen JA, et al. Lifting the mouth corner: a systematic review of techniques, clinical outcomes, and patient satisfaction. Aesthet Surg J. 2022;42:833–841. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 42.Bertossi D, Giampaoli G, Dell’Acqua I, et al. Nonsurgical genioplasty. Dermatol Ther. 2019;32:e12874. [DOI] [PubMed] [Google Scholar]
- 43.Kapoor KM, Saputra DI, Porter CE, et al. Treating aging changes of facial anatomical layers with hyaluronic acid fillers. Clin Cosmet Investig Dermatol. 2021;14:1105–1118. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 44.Wilson AJ, Taglienti AJ, Chang CS, et al. Current applications of facial volumization with fillers. Plast Reconstr Surg. 2016;137:872e–889e. [DOI] [PubMed] [Google Scholar]
- 45.Kaminer MS, Cohen JL, Shamban A, et al. Maximizing panfacial aesthetic outcomes: findings and recommendations from the HARMONY study. Dermatol Surg. 2020;46:810–817. [DOI] [PubMed] [Google Scholar]
- 46.Braz A, Eduardo CCP. Reshaping the lower face using injectable fillers. Indian J Plast Surg. 2020;53:207–218. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 47.Ascha M, Swanson MA, Massie JP, et al. Nonsurgical management of facial masculinization and feminization. Aesthet Surg J. 2019;39:NP123–NP137. [DOI] [PubMed] [Google Scholar]
- 48.Cohen JL, Rivkin A, Dayan S, et al. Multimodal facial aesthetic treatment on the appearance of aging, social confidence, and psychological wellbeing: HARMONY study. Aesthet Surg J. 2022;42:NP115–NP124. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49.Bertucci V, Rivers JK, Humphrey S, et al. Canada HARMONY study: comprehensive panfacial approach to aesthetic treatment, including submental fullness, results in improved patient-reported outcomes. Talk presented at: Annual Meeting of the American Society for Dermatologic Surgery; November 19–21, 2021 [Virtual Meeting]. [Google Scholar]
- 50.Dayan S, Rivkin A, Sykes JM, et al. Aesthetic treatment positively impacts social perception: analysis of subjects from the HARMONY study. Aesthet Surg J. 2019;39:1380–1389. [DOI] [PubMed] [Google Scholar]
- 51.Montes JR, Ubale RV. Patient satisfaction and patients’ family or significant other perceptions after onabotulinumtoxinA treatment: a prospective cross-sectional study. Dermatol Surg. 2019;45:1069–1079. [DOI] [PubMed] [Google Scholar]
- 52.Cotofana S, Schenck TL, Trevidic P, et al. Midface: clinical anatomy and regional approaches with injectable fillers. Plast Reconstr Surg. 2015;136:219S–234S. [DOI] [PubMed] [Google Scholar]
- 53.Hsu AK, Frankel AS. Modification of chin projection and aesthetics with onabotulinumtoxinA injection. JAMA Facial Plast Surg. 2017;19:522–527. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 54.Humphrey S, Cohen JL, Bhatia AC, et al. Improvements in submental contour up to 3 years after ATX-101: efficacy and safety follow-up of the phase 3 REFINE trials. Aesthet Surg J. 2021;41:NP1532–NP1539. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 55.Jones D, Palm M, Cox SE, et al. Safety and effectiveness of hyaluronic acid filler, VYC-20L, via cannula for cheek augmentation: a randomized, single-blind, controlled study. Dermatol Surg. 2021;47:1590–1594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 56.Philipp-Dormston WG, Goodman GJ, De Boulle K, et al. Global approaches to the prevention and management of delayed-onset adverse reactions with hyaluronic acid-based fillers. Plast Reconstr Surg Glob Open. 2020;8:e2730. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 57.Jones DH, Fitzgerald R, Cox SE, et al. Preventing and treating adverse events of injectable fillers: evidence-based recommendations from the American Society for Dermatologic Surgery multidisciplinary task force. Dermatol Surg. 2021;47:214–226. [DOI] [PubMed] [Google Scholar]
- 58.Braz A, Eduardo CCP. The facial shapes in planning the treatment with injectable fillers. Indian J Plast Surg. 2020;53:230–243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 59.Sundaram H, Signorini M, Liew S, et al. Global Aesthetics Consensus Group. Global aesthetics consensus group: botulinum toxin type 1—evidence-based review, emerging concepts, and consensus recommendations for aesthetic use, including updates on complications. Plast Reconstr Surg. 2016;137:518e–529e. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 60.Fagien S, McChesney P, Subramanian M, et al. Prevention and management of injection-related adverse effects in facial aesthetics: considerations for ATX-101 (deoxycholic acid injection) treatment. Dermatol Surg. 2016;42:S300–S304. [DOI] [PubMed] [Google Scholar]
- 61.van Loghem J, Sattler S, Casabona G, et al. Consensus on the use of hyaluronic acid fillers from the cohesive polydensified matrix range: best practice in specific facial indications. Clin Cosmet Investig Dermatol. 2021;14:1175–1199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 62.Jones D, Murphy DK. Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013;39:1602–1612. [DOI] [PubMed] [Google Scholar]
- 63.de Maio M. MD codes: a methodological approach to facial aesthetic treatment with injectable hyaluronic acid fillers. Aesthetic Plast Surg. 2021;45:690–709. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 64.Few J, Cox SE, Paradkar-Mitragotri D, et al. A multicenter, single-blind randomized, controlled study of a volumizing hyaluronic acid filler for midface volume deficit: patient-reported outcomes at 2 years. Aesthet Surg J. 2015;35:589–599. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 65.de la Guardia C, Virno A, Musumeci M, et al. Rheologic and physicochemical characteristics of hyaluronic acid fillers: overview and relationship to product performance. Facial Plast Surg. 2022;38:116–123. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 66.Alexiades M, Palm MD, Kaufman-Janette J, et al. A randomized, multicenter, evaluator-blind study to evaluate the safety and effectiveness of VYC-12L treatment for skin quality improvements. Dermatol Surg. 2023;49:682–688. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 67.Chiu A, Montes JR, Munavalli G, et al. Improved patient satisfaction with skin after treatment of cheek skin roughness and fine lines with VYC-12L: participant-reported outcomes from a prospective, randomized study. Aesthet Surg J. 2023;43:1367–1375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 68.Narurkar VA, Cohen JL, Dayan S, et al. A comprehensive approach to multimodal facial aesthetic treatment: injection techniques and treatment characteristics from the HARMONY study. Dermatol Surg. 2016;42:S177–S191. [DOI] [PubMed] [Google Scholar]
- 69.Pecora NG, Baccetti T, McNamara JA, Jr. The aging craniofacial complex: a longitudinal cephalometric study from late adolescence to late adulthood. Am J Orthod Dentofacial Orthop. 2008;134:496–505. [DOI] [PubMed] [Google Scholar]
- 70.Goodman GJ, Subramanian M, Sutch S, et al. Beauty from the neck up: introduction to the special issue. Dermatol Surg. 2016;42:S260–S262. [DOI] [PubMed] [Google Scholar]
- 71.Sykes JM, Fitzgerald R. Choosing the best procedure to augment the chin: is anything better than an implant? Facial Plast Surg. 2016;32:507–512. [DOI] [PubMed] [Google Scholar]
- 72.Bertossi D, Robiony M, Lazzarotto A, et al. Nonsurgical redefinition of the chin and jawline of younger adults with a hyaluronic acid filler: results evaluated with a grid system approach. Aesthet Surg J. 2021;41:1068–1076. [DOI] [PubMed] [Google Scholar]
- 73.Mastroluca E, Patalano M, Bertossi D. Minimally invasive aesthetic treatment of male patients: the importance of consultation and the lower third of the face. J Cosmet Dermatol. 2021;20:2086–2092. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 74.Beer K, Kaufman-Janette J, Bank D, et al. Safe and effective chin augmentation with the hyaluronic acid injectable filler, VYC-20L. Dermatol Surg. 2021;47:80–85. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 75.Ogilvie P, Sattler G, Gaymans F, et al. Safe, effective chin and jaw restoration with VYC-25L hyaluronic acid injectable gel. Dermatol Surg. 2019;45:1294–1303. [DOI] [PubMed] [Google Scholar]
- 76.Ogilvie P, Benouaiche L, Philipp-Dormston WG, et al. VYC-25L hyaluronic acid injectable gel is safe and effective for long-term restoration and creation of volume of the lower face. Aesthet Surg J. 2020;40:NP499–NP510. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 77.Rivkin A, Green JB, Bruce S, et al. Safe and effective restoration of jawline definition with hyaluronic acid injectable gel VYC-25L: results from a randomized, controlled study. Aesthet Surg J. 2024:sjae147.. Online ahead of print. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 78.Kundu N, Kothari R, Shah N, et al. Efficacy of botulinum toxin in masseter muscle hypertrophy for lower face contouring. J Cosmet Dermatol. 2022;21:1849–1856. [DOI] [PubMed] [Google Scholar]
- 79.Kridel RWH, Patel S. Cheek and chin implants to enhance facelift results. Facial Plast Surg. 2017;33:279–284. [DOI] [PubMed] [Google Scholar]
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