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. 2024 Sep 3;27(10):2021–2032. doi: 10.1038/s41593-024-01742-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a,b, Heat maps depicting disease enrichment of age-regulated DE genes (at FDR-adjusted P < 0.05) across cell types for downregulated (a) and upregulated (b) DE genes. Only cell types with a minimum of one disease ontology term were included. Colors represent the number of genes (count) contributing to the disease ontology term. Significance was determined using a one-sided Fisher’s exact test, followed by multiple testing correction (FDR). Asterisks (*) indicate an FDR-adjusted P < 0.05. Gray values indicate not applicable. Only enrichment for brain-related diseases is shown.