Table 3.
Univariable and multivariable Cox proportional hazards model for event-free survival (EFS) in cN+ patients with and without a clipped node
| EFS univariate analysis | EFS multivariate analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Characteristic | N | Event N | HRa | 95% CIa | p valueb | HRa | 95% CIa | p valueb |
| Clip placement | ||||||||
| No clip placed | 639 | 128 | – | – | – | – | ||
| Clip placed and clipped node retrieved | 127 | 11 | 0.48 | 0.26, 0.89 | 0.019 | 0.85 | 0.42, 1.74 | 0.7 |
| Clip placed, but clipped node not retrieved | 21 | 3 | 0.76 | 0.24, 2.38 | 0.6 | 1.80 | 0.54, 6.01 | 0.3 |
| Age at screening | 801 | 146 | 1.00 | 0.98, 1.01 | 0.5 | 1.00 | 0.98, 1.01 | 0.8 |
| Surgery year | ||||||||
| 2011 | 41 | 13 | – | – | – | – | ||
| 2012 | 59 | 12 | 0.65 | 0.30, 1.43 | 0.3 | 0.66 | 0.29, 1.50 | 0.3 |
| 2013 | 70 | 17 | 0.80 | 0.39, 1.65 | 0.5 | 1.05 | 0.50, 2.19 | 0.9 |
| 2014 | 74 | 16 | 0.71 | 0.34, 1.47 | 0.4 | 0.56 | 0.26, 1.19 | 0.13 |
| 2015 | 78 | 17 | 0.73 | 0.36, 1.51 | 0.4 | 0.69 | 0.33, 1.46 | 0.3 |
| 2016 | 62 | 12 | 0.68 | 0.31, 1.49 | 0.3 | 0.59 | 0.26, 1.37 | 0.2 |
| 2017 | 78 | 17 | 0.80 | 0.39, 1.66 | 0.6 | 0.78 | 0.36, 1.68 | 0.5 |
| 2018 | 76 | 13 | 0.72 | 0.33, 1.56 | 0.4 | 0.74 | 0.33, 1.66 | 0.5 |
| 2019 | 114 | 14 | 0.53 | 0.25, 1.13 | 0.10 | 0.72 | 0.32, 1.63 | 0.4 |
| 2020 | 80 | 7 | 0.46 | 0.18, 1.17 | 0.10 | 0.62 | 0.22, 1.71 | 0.4 |
| 2021 | 69 | 8 | 0.86 | 0.35, 2.13 | 0.8 | 0.00 | 0.00, inf. | > 0.9 |
| Race | ||||||||
| White | 630 | 113 | – | – | – | – | ||
| Asian | 53 | 8 | 0.81 | 0.40, 1.67 | 0.6 | 0.62 | 0.29, 1.33 | 0.2 |
| Black | 103 | 24 | 1.35 | 0.87, 2.10 | 0.2 | 1.24 | 0.75, 2.04 | 0.4 |
| Other | 15 | 1 | 0.41 | 0.06, 2.94 | 0.4 | 1.27 | 0.17, 9.52 | 0.8 |
| Ethnicity | ||||||||
| Not Hispanic or Latino | 699 | 130 | – | – | – | – | ||
| Hispanic or Latino | 98 | 16 | 0.92 | 0.55, 1.55 | 0.8 | 1.22 | 0.69, 2.16 | 0.5 |
| Unknown | 4 | 0 | 0.00 | 0.00, Inf | > 0.9 | 0.00 | 0.00, inf. | > 0.9 |
| Clinical T Category at diagnosis | ||||||||
| T1/T2 | 485 | 67 | – | – | – | – | ||
| T3/T4 | 316 | 79 | 2.04 | 1.47, 2.82 | < 0.001 | 1.52 | 1.05, 2.21 | 0.026 |
| Clinical N category at diagnosis | ||||||||
| N1 | 647 | 102 | – | – | – | – | ||
| N2 | 66 | 25 | 2.78 | 1.80, 4.31 | <0.001 | 2.77 | 1.72, 4.47 | < 0.001 |
| N3 | 88 | 19 | 1.49 | 0.91, 2.43 | 0.11 | 2.08 | 1.20, 3.60 | 0.009 |
| Tumor receptor subtype | ||||||||
| HR+ HER2– | 401 | 68 | – | – | – | – | ||
| HER2+ | 181 | 20 | 0.59 | 0.36, 0.97 | 0.037 | 1.11 | 0.64, 1.91 | 0.7 |
| HR– HER2– | 219 | 58 | 1.70 | 1.20, 2.42 | 0.003 | 2.72 | 1.83, 4.05 | < 0.001 |
| RCB class | ||||||||
| 0 | 260 | 14 | – | – | – | – | ||
| 1 | 100 | 15 | 2.89 | 1.40, 5.99 | 0.004 | 2.29 | 1.02, 5.15 | 0.045 |
| 2 | 273 | 60 | 4.52 | 2.53, 8.09 | <0.001 | 5.89 | 3.11, 11.2 | < 0.001 |
| 3 | 168 | 57 | 7.55 | 4.21, 13.6 | <0.001 | 8.55 | 4.39, 16.6 | < 0.001 |
| Type of axillary surgery | ||||||||
| All other axillary surgery | 480 | 112 | – | – | – | – | ||
| SLN surgery only | 321 | 34 | 0.48 | 0.33, 0.71 | <0.001 | 0.67 | 0.38, 1.18 | 0.2 |
| Type of breast surgery | ||||||||
| Partial mastectomy | 281 | 39 | – | – | – | – | ||
| Nipple sparing mastectomy | 107 | 17 | 1.21 | 0.69, 2.15 | 0.5 | 1.14 | 0.62, 2.08 | 0.7 |
| Skin sparing mastectomy | 111 | 19 | 1.30 | 0.75, 2.25 | 0.3 | 0.98 | 0.53, 1.82 | > 0.9 |
| Total mastectomy | 235 | 62 | 1.97 | 1.32, 2.94 | < 0.001 | 1.35 | 0.85, 2.14 | 0.2 |
| Total Nodes Removed | 801 | 146 | 1.02 | 1.01, 1.04 | 0.009 | 0.99 | 0.96, 1.01 | 0.3 |
HR hazard ratio, CI confidence interval, HR hormone receptor, HER2 human epidermal growth factor receptor 2, RCB residual cancer burden, SLN sentinel lymph node
aHR hazard ratio, CI confidence interval
bWald test