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. 2024 Oct 5;15:8641. doi: 10.1038/s41467-024-52984-1

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — a Experimental design. Mice containing Slc1a3-CreERT and Ai9 reporter are injected with tamoxifen to induce expression of modified red fluorescent protein (tdTomato) in cells expressing Slc1a3. b Top row, tdTomato expression (red) 1, 30, and 360 days post induction (DPI) with tamoxifen. Lower rows, tdTomato+ progeny of Slc1a3+ cells express differentiation markers for stem (SLC1A3, orange, arrows), ciliated (FAM183B, orange, arrows), and secretory (OVGP1, orange, arrows) cells. Counterstaining with DAPI (blue). Scale bar represents 50 μm (tdTomato, FAM1A3/tdTomato, OVGP1/tdTomato rows), and 25 μm (SLC1A3/tdTomato row). c Quantification of cells expressing tdTomato in the distal and proximal regions of the uterine tube 1, 30, and 360 DPI. Quantification of cells expressing tdTomato with stem (SLC1A3, d), ciliated (FAM183B, e), or secretory (OVGP1, f) cells 1, 30, and 360 DPI. c–f Two way ANOVA with the Tukey’s multiple comparison post hoc test for all distal regions. c ***P = 0.0003, ****P < 0.0001 (d) ****P < 0.0001 (e) ****P < 0.0001 (f) *P = 0.0146, **P = 0.0058, ****P < 0.0001. Data are presented as mean values ± SD. Biological replicates (mice, n): c Distal 1 DPI n = 6, 30 DPI n = 4, 360 DPI n = 3; Proximal 1 DPI n = 4, 30, and 360 DPI n = 3 each group. d Distal and Proximal n = 3 each group. e Distal 1 DPI n = 6, 30 DPI and 360 DPI n = 4 each group; Proximal 1 DPI n = 4, 30, and 360 DPI n = 3 each group. f Distal 1 DPI n = 6, 30, and 360 DPI n = 4 each group; Proximal n = 3, each group. Source data are provided as a Source Data file.