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. 2024 Oct 5;15:8641. doi: 10.1038/s41467-024-52984-1

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© The Author(s) 2024, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — a Detection of ciliation FOXJ1 (green) and TRP73 (green) markers but not secretory marker OVGP1 (green) in Krt5+ (tdTomato) cells and their progeny (arrows) in the distal tubal epithelium 1 and 30 days post-induction (DPI) with tamoxifen in Krt5-CreERT Ai9 mice. b Quantification of Krt5+ cells co-expressing tdTomato with OVGP1, FOXJ1 or TRP73 1 and 30 DPI. **P = 0.0017, ****P < 0.0001, two-tailed unpaired t-tests. Data are presented as mean values ± SD. Biological replicates n = 3 in each group. Source data are provided as a Source Data file. c–f Neoplastic lesions in Krt5-CreERT Trp53^loxP/loxP Rb1^loxP/loxP Ai9 mice. Early dysplastic lesions (arrows) with mild cellular atypia (c) and more pronounced atypical features, loss of cell polarity, and high proliferative index typical for STICs (d). Arrowheads in (c), TE-mesothelial junctions. Advanced neoplastic lesions (arrows) with stromal invasion (e) and peritoneal spreading (f, arrows). Hematoxylin and Eosin (HE) staining and immunostainings for PAX8, Wilms tumor 1 (WT1), Ki67, p16, and tdTomato (brown color) by Elite ABC method with hematoxylin counterstaining. Scale bar 50 µm (a, c, except for right image, and d) and 100 µm (c), right image, (e, f). Biological replicates n = 5 (c), n = 8 (d), n = 4 (e) and n = 3 (f).