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. 2024 Oct 5;15:8641. doi: 10.1038/s41467-024-52984-1

Fig. 8. Cell lineage hierarchy and cancer-prone cell state of the distal tubal epithelium.

Fig. 8

The hierarchy begins with Slc1a3+ stem/progenitor cells giving rise to secretory and ciliated cell lineages. Slc1a3+ stem/progenitor cells undergo apoptosis after inactivation of Trp53 alone or together with Rb1, while inactivation of Trp53 and Rb1 in Krt5+ pre-ciliated transitional cells lead to high-grade serous carcinoma. Colors of epithelial cells resemble the colors used to label cells within UMAP embeddings (Fig. 2a).