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. 2024 Oct 4;10:87. doi: 10.1038/s41523-024-00693-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — a Case 1 is an analysis of bilateral risk-reducing mastectomy in a 45-year-old woman with BRCA1 p.Q1281*. She has a history of right breast cancer and underwent partial mastectomy followed by adjuvant chemoradiotherapy. In the right breast, 14 specimens from 53 samples had mutations in PIK3CA, ARHGAP35, CDH1, and NF1, and the clonality score was 2.42. Phylogenetic tree analysis of 8 samples (green highlighted) using WES data are shown. b Overall 6 of 58 samples in the left breast had mutations in PIK3CA, and the clonality score was 0.99. Phylogenetic tree analysis of 3 samples (green highlighted) using WES data are shown. c The representative microscopic images of breast tissue with hematoxylin and eosin (HE) staining. The left picture shows sclerosing adenosis. Magnification, ×100. Scale bars represent 200 μm. Lt left, Rt right, GL germline.