Table 3.

Summary of apparent binding affinities of C4 stereoisomers

		ERK2 Kiapp/µM	p38 Kiapp/µM	JNK1 Kiapp/µM
3R		12.3 ± 0.4	1.7 ± 0.1	23.6 ± 1.5
3S		4.9 ± 0.2	8.3 ± 0.7	6.5 ± 0.6
8R		5.9 ± 0.4	0.8 ± 0.1	1.2 ± 0.3
8S		6.3 ± 0.3	0.8 ± 0.1	1.8 ± 0.4
12R		10.1 ± 1.0	4.8 ± 0.4	27.6 ± 3.9
12S		24.7 ± 1.5	5.5 ± 0.6	15.3 ± 2.4
6S,S		66.7 ± 5.1	6.2 ± 0.4	8.0 ± 0.7
6R,R		8.4 ± 0.7	0.6 ± 0.0	1.0 ± 0.1

Data show the mean ± parameter error estimates from weighted least square method, see Supplementary Fig. 13.