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. 2024 Sep 5;16(9):e68691. doi: 10.7759/cureus.68691

Table 2. Characteristics of first, second, and third generation of LVADs.

LVADs: Left ventricular assist devices

LVADs Technology Advantages Disadvantages
First generation [18 Pulsatile flow Mimics natural heart function and immediate support. Large size, high infection rate, mechanical failures, and limited durability.
Second generation [21 Continuous flow with axial pumps Smaller, lower infection rates, improved survival, better symptom management - Better management of severe heart failure symptoms GI bleeding, thrombosis, and infection risk from external power.  
Third generation [22]   Continuous-flow technology with centrifugal flow pumps Longer durability, easier placement, lower stroke risk, and better quality of life. Complex, expensive, requiring specialized training, and external power dependence.