FIGURE 2.

Specific activity of small molecules of known anti-prion and anti-amyloid activities in mouse prion strains. Sixteen small molecules with proven anti-prion or anti-amyloid activities (dissolved in DMSO) were tested at four different concentrations for their anti-prion activities against the RML (A), 301C (B) and ME7 (C) prion strains using the 96wp-PMCA. Each molecule was tested in concentrations ranging from 100 to 0.1 μM. Controls for solvent representative for all strains, positive samples and negative samples without compounds were included to monitor the assay. Dot blots were modified for labeling. The panels shown in this figure are representative from three independent assays.