FIG. 3.

Vaginal antibody responses after i.n. and oral administration to BALB/c mice of rNV VLPs in the presence or absence of LT(R192G). (A and B) Vaginal responses at 40 dpi (A) and 365 dpi (B). The GMT was calculated, including responders and nonresponders. The error bars show the standard error of the mean. Above each column is the number of responders over the total number of mice tested, and the GMT of only the responders is shown in parentheses. The y axis on the left panel shows the GMT of antibody for each group of mice, and the y axis on the right panel represents the response expressed as mean of the ratio of NV-specific IgA in nanograms per milliliter to total IgA in micrograms per milliliter. Statistical analysis was done with the Mann-Whitney U test. Identical symbols above two different columns indicate that these two groups were significantly different.