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Retention of the Trp53 wild-type allele in spontaneous and MMLV-induced thymic lymphomas in CD2-myc Trp53+/− mice
| MMLV status | No. of tumors with Trp53 allele retentiona/no. tested |
|---|---|
| Infected | 19/27 |
| Uninfected | 0/13 |
Tumors were judged to have retained the Trp53 allele if the intensity of the wild-type band was >90% of that of the Trp53 pseudogene on the same Southern blot (Fig. 2A). Tumors regarded as having LOH showed reductions of 30 to 100%.
