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Fine specificity of CD8+ T-cell clones to singly substituted Tax11-19 analogues. T-cell recognition of Tax11-19 peptide analogues at TCR P5 and P8 pockets in Tax11-19-reactive CD8+ T-cell clones expressing strong structural similarities is shown. The peptide recognition was determined by a standard 4-h 51Cr release assay. HLA-A*0201-expressing EBV-transformed B-cell lines were pulsed with peptides at 10 μM and used as target cells. The effector-to-target ratio was 10:1. AA, amino acid.
