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. Author manuscript; available in PMC: 2025 Oct 3.
Published in final edited form as: Structure. 2024 Jul 30;32(10):1751–1759.e4. doi: 10.1016/j.str.2024.07.004

Figure 1. Structure of the CRX HD-Ret4 complex.

Figure 1.

A. An overview. The structure features two molecules of CRX HD bound to DNA. CRX HD is rainbow colored with the N-terminus in blue and the C-terminus in red. α3-helix of the CRX HD binds to the major DNA groove while the N terminal arm inserts into the minor groove. B. Interactions of CRX HD chain A with nucleotide bases. R43 makes hydrogen bonding interactions with adjacent T and A (TAAG), whereas N89 makes hydrogen bonding interaction with A (TAAG) in the antisense strand. C. Interactions of CRX HD chain B with nucleotide bases. R43 makes contact with TT (bold, TTAG) of sense strand and G of antisense strand (bold, TAAG), whereas N89 makes hydrogen bonding interaction with A (TAAG) in the sense strand.